ZMYND11

Zinc finger MYND domain-containing protein 11 is a protein that in humans is encoded by the ZMYND11 gene.[5][6][7]

ZMYND11
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesZMYND11, BRAM1, BS69, MRD30, zinc finger MYND-type containing 11
External IDsOMIM: 608668 MGI: 1913755 HomoloGene: 4828 GeneCards: ZMYND11
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10p15.3Start134,465 bp[1]
End254,637 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10771

66505

Ensembl

ENSG00000015171

ENSMUSG00000021156

UniProt

Q15326

Q8R5C8

RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 10: 0.13 – 0.25 MbChr 13: 9.68 – 9.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

Interactions

ZMYND11 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000015171 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021156 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hateboer G, Gennissen A, Ramos YF, Kerkhoven RM, Sonntag-Buck V, Stunnenberg HG, Bernards R (Jul 1995). "BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation". The EMBO Journal. 14 (13): 3159–69. doi:10.1002/j.1460-2075.1995.tb07318.x. PMC 394377. PMID 7621829.
  6. Masselink H, Bernards R (Mar 2000). "The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR". Oncogene. 19 (12): 1538–46. doi:10.1038/sj.onc.1203421. PMID 10734313.
  7. "Entrez Gene: ZMYND11 zinc finger, MYND domain containing 11".
  8. Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H (Apr 1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling". Genes to Cells. 3 (4): 257–64. doi:10.1046/j.1365-2443.1998.00186.x. PMID 9663660. S2CID 29818690.
  9. Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T (Nov 2003). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer". Cell. 115 (5): 523–35. doi:10.1016/s0092-8674(03)00930-9. PMID 14651845. S2CID 18911371.
  10. Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Research. 23 (3A): 2173–8. PMID 12894593.
  11. Wen, Hong; Li, Yuanyuan; Xi, Yuanxin; Jiang, Shiming; Stratton, Sabrina; Peng, Danni; Tanaka, Kaori; Ren, Yongfeng; Xia, Zheng; Wu, Jun; Li, Bing; Barton, Michelle C.; Li, Wei; Li, Haitao; Shi, Xiaobing (2014). "ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression". Nature. 508 (7495): 263–268. doi:10.1038/nature13045. PMC 4142212. PMID 24590075.

Further reading


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