ZRSR2

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 is a protein that in humans is encoded by the ZRSR2 gene.[5][6][7][8]

ZRSR2
Identifiers
AliasesZRSR2, U2AF1-RS2, U2AF1L2, U2AF1RS2, URP, ZC3H22, zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
External IDsOMIM: 300028 MGI: 103287 HomoloGene: 21061 GeneCards: ZRSR2
Gene location (Human)
Chr.X chromosome (human)[1]
BandXp22.2Start15,790,472 bp[1]
End15,823,260 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8233

22184

Ensembl

ENSG00000169249

ENSMUSG00000031370

UniProt

Q15696

Q62377

RefSeq (mRNA)

NM_005089

NM_009453
NM_178794

RefSeq (protein)

NP_005080

n/a

Location (UCSC)Chr X: 15.79 – 15.82 MbChr X: 163.94 – 163.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000169249 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031370 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kitagawa K, Wang X, Hatada I, Yamaoka T, Nojima H, Inazawa J, Abe T, Mitsuya K, Oshimura M, Murata A, et al. (Mar 1996). "Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1". Genomics. 30 (2): 257–63. doi:10.1006/geno.1995.9879. PMID 8586425.
  6. Tronchere H, Wang J, Fu XD (Aug 1997). "A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA". Nature. 388 (6640): 397–400. doi:10.1038/41137. PMID 9237760. S2CID 4386808.
  7. Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Luhrmann R (May 2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
  8. "Entrez Gene: ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2".

Further reading


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