CDC34

CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1.[5][6][7] This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins.[8]

CDC34
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDC34, E2-UBC3, UBCH3, UBE2R1, cell division cycle 34, cell division cycle 34, ubiqiutin conjugating enzyme
External IDsOMIM: 116948 MGI: 102657 HomoloGene: 55815 GeneCards: CDC34
EC number2.3.2.24
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.3Start531,760 bp[1]
End542,092 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

997

216150

Ensembl

ENSG00000099804

ENSMUSG00000020307

UniProt

P49427

Q8CFI2

RefSeq (mRNA)

NM_004359

NM_177613
NM_001359817
NM_001359818

RefSeq (protein)

NP_004350

NP_808281
NP_001346746
NP_001346747

Location (UCSC)Chr 19: 0.53 – 0.54 MbChr 10: 79.68 – 79.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CDC34 was originally discovered by work in baker's yeast as a gene that is essential for the cell cycle.[9] Cdc34 in yeast targets numerous substrates - notably the cyclin-dependent kinase inhibitor Sic1[10] - for ubiquitin-mediated protein degradation.[11] CDC34 is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.[7]

Interactions

CDC34 has been shown to interact with CSNK2B,[12] BTRC[13][14] and CDK9.[15]

References

  1. GRCh38: Ensembl release 89: ENSG00000099804 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020307 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Plon SE, Leppig KA, Do HN, Groudine M (November 1993). "Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast". Proceedings of the National Academy of Sciences of the United States of America. 90 (22): 10484–8. Bibcode:1993PNAS...9010484P. doi:10.1073/pnas.90.22.10484. PMC 47801. PMID 8248134.
  6. Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, et al. (October 2005). "Proximity-induced activation of human Cdc34 through heterologous dimerization". Proceedings of the National Academy of Sciences of the United States of America. 102 (42): 15053–8. Bibcode:2005PNAS..10215053G. doi:10.1073/pnas.0507646102. PMC 1242854. PMID 16210246.
  7. "Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)".
  8. Goebl MG, Yochem J, Jentsch S, McGrath JP, Varshavsky A, Byers B (September 1988). "The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme". Science. 241 (4871): 1331–5. doi:10.1126/science.2842867. PMID 2842867.
  9. Dutcher SK, Hartwell LH (February 1982). "The role of S. cerevisiae cell division cycle genes in nuclear fusion". Genetics. 100 (2): 175–84. PMID 7049831.
  10. King RW, Deshaies RJ, Peters JM, Kirschner MW (December 1996). "How proteolysis drives the cell cycle". Science. 274 (5293): 1652–9. doi:10.1126/science.274.5293.1652. PMID 8939846.
  11. Williams KM, Qie S, Atkison JH, Salazar-Arango S, Alan Diehl J, Olsen SK (July 2019). "Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34". Nature Communications. 10 (1): 3296. doi:10.1038/s41467-019-11061-8. PMID 31341161.
  12. Block K, Boyer TG, Yew PR (November 2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". The Journal of Biological Chemistry. 276 (44): 41049–58. doi:10.1074/jbc.M106453200. PMID 11546811.
  13. Semplici F, Meggio F, Pinna LA, Oliviero S (June 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. PMID 12037680.
  14. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
  15. Kiernan RE, Emiliani S, Nakayama K, Castro A, Labbé JC, Lorca T, et al. (December 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Molecular and Cellular Biology. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. PMC 99964. PMID 11689688.

Further reading


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