1-(2-Chloro-N-methylbenzimidoyl)cyclopentanol

1-(2-Chloro-N-methylbenzimidoyl)cyclopentanol
Identifiers
	IUPAC name 1-[C-(2-chlorophenyl)-N-methylcarbonimidoyl]cyclopentan-1-ol;
CAS Number	6740-87-0; hydrochloride: 90717-16-1;
PubChem CID	13086940;
ChemSpider	26551984;
UNII	HGI99H315N;
CompTox Dashboard (EPA)	DTXSID60217758 ;
ECHA InfoCard	100.169.732
Chemical and physical data
Formula	C13H16ClNO
Molar mass	237.73 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN=C(C1=CC=CC=C1Cl)C2(CCCC2)O;
	InChI InChI=1S/C13H16ClNO/c1-15-12(13(16)8-4-5-9-13)10-6-2-3-7-11(10)14/h2-3,6-7,16H,4-5,8-9H2,1H3; Key:FJGPXUPMNZOTLX-UHFFFAOYSA-N;

1-(2-Chloro-N-methylbenzimidoyl)cyclopentanol, sometimes misleadingly referred to as hydroxylimine hydrochloride, is a chemical compound which is the final intermediate in the synthesis of ketamine, an anaesthetic drug which is also subject to recreational abuse. This chemical intermediate is not active as a drug in its own right, and is legal in most countries, but is readily converted into ketamine by dissolving it in a suitable high-boiling point solvent and heating, with no other chemicals required.[1][2] This has made it subject to illicit trade as a drug precursor, and it has sometimes been seized by law enforcement agencies in significant quantities, leading to it being specifically banned as a controlled drug precursor in some jurisdictions such as Taiwan.[3][4]

References

US patent 3254124, Stevens CL, "Aminoketones and methods for their production", issued 1966-05-31, assigned to Parke Davis & Co.
Dimitrov I, Denny WA, Jose J (2018). "Syntheses of Ketamine and Related Analogues: A Mini Review". Synthesis. 50 (21): 4201–4215. doi:10.1055/s-0037-1609935.
"200 kg of ketamine precursor seized at Taoyuan Airport". Taiwan News. 1 January 2009.
"Taiwan catches 2 tons of drugs hidden inside machinery from China". Taiwan News. 31 March 2018.

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[1] US patent 3254124, Stevens CL, "Aminoketones and methods for their production", issued 1966-05-31, assigned to Parke Davis & Co.

[2] Dimitrov I, Denny WA, Jose J (2018). "Syntheses of Ketamine and Related Analogues: A Mini Review". Synthesis. 50 (21): 4201–4215. doi:10.1055/s-0037-1609935.

[3] "200 kg of ketamine precursor seized at Taoyuan Airport". Taiwan News. 1 January 2009.

[4] "Taiwan catches 2 tons of drugs hidden inside machinery from China". Taiwan News. 31 March 2018.

1-(2-Chloro-N-methylbenzimidoyl)cyclopentanol

See also

References