2,3-dihydroxybenzoate 2,3-dioxygenase
In enzymology, a 2,3-dihydroxybenzoate 2,3-dioxygenase (EC 1.13.11.28) is an enzyme that catalyzes the chemical reaction
- 2,3-dihydroxybenzoate + O2 2-carboxy-cis,cis-muconate
| 2,3-dihydroxybenzoate 2,3-dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.13.11.28 | ||||||||
| CAS number | 56802-97-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 2,3-dihydroxybenzoate and O2, whereas its product is 2-carboxy-cis,cis-muconate.
This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is 2,3-dihydroxybenzoate:oxygen 2,3-oxidoreductase (decyclizing). This enzyme is also called 2,3-dihydroxybenzoate 2,3-oxygenase.
References
- Stein MB, Seedat S, Gelernter J (July 2006). "Serotonin transporter gene promoter polymorphism predicts SSRI response in generalized social anxiety disorder". Psychopharmacology. 187 (1): 68–72. doi:10.1007/s00213-006-0349-8. PMID 16525856.
- Sharma HK, Vaidyanathan CS (1975). "A new mode of ring cleavage of 2,3-dihydroxybenzoic acid in Tecoma stans (L.). Partial purification and properties of 2,3-dihydroxybenzoate 2,3-oxygenase". Eur. J. Biochem. 56 (1): 163–71. doi:10.1111/j.1432-1033.1975.tb02219.x. PMID 1175620.
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