23S rRNA pseudouridine2457 synthase

23S rRNA pseudouridine2457 synthase (EC 5.4.99.20, RluE, YmfC) is an enzyme with systematic name 23S rRNA-uridine2457 uracil mutase.[1][2] This enzyme catalyses the following chemical reaction

23S rRNA uridine2457 23S rRNA pseudouridine2457
23S rRNA pseudouridine2457 synthase
Identifiers
EC number5.4.99.20
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme modifies uridine2457 in a stem of 23S RNA in Escherichia coli.

References

  1. Del Campo M, Kaya Y, Ofengand J (November 2001). "Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli". RNA. 7 (11): 1603–15. PMC 1370202. PMID 11720289.
  2. Pan H, Ho JD, Stroud RM, Finer-Moore J (April 2007). "The crystal structure of E. coli rRNA pseudouridine synthase RluE". Journal of Molecular Biology. 367 (5): 1459–70. doi:10.1016/j.jmb.2007.01.084. PMC 1876706. PMID 17320904.
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