3-oxo-5beta-steroid 4-dehydrogenase
In enzymology, a 3-oxo-5beta-steroid 4-dehydrogenase (EC 1.3.99.6) is an enzyme that catalyzes the chemical reaction
- a 3-oxo-5beta-steroid + acceptor a 3-oxo-Delta4-steroid + reduced acceptor
| 3-oxo-5-beta-steroid 4-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.99.6 | ||||||||
| CAS number | 9067-97-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 3-oxo-5beta-steroid and acceptor, whereas its two products are 3-oxo-Delta4-steroid and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 3-oxo-5beta-steroid:acceptor Delta4-oxidoreductase. This enzyme is also called 3-oxo-5beta-steroid:(acceptor) Delta4-oxidoreductase. This enzyme participates in 3 metabolic pathways: bile acid biosynthesis, c21-steroid hormone metabolism, and androgen and estrogen metabolism.
References
- Davidson SJ, Talalay P (1966). "Purification and mechanism of action of a steroid delta-4-5-beta-dehydrogenase". J. Biol. Chem. 241 (4): 906–15. PMID 5907467.
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