4-hydroxybenzoyl-CoA reductase

In enzymology, a 4-hydroxybenzoyl-CoA reductase (EC 1.3.7.9) is an enzyme found in some bacteria and archaea that catalyzes the chemical reaction[1][2]

benzoyl-CoA + acceptor + H2O 4-hydroxybenzoyl-CoA + reduced acceptor
4-hydroxybenzoyl-CoA reductase
Identifiers
EC number1.3.7.9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

The 3 substrates of this enzyme are benzoyl-CoA, acceptor, and H2O, whereas its two products are 4-hydroxybenzoyl-CoA and reduced acceptor.

This enzyme participates in benzoate degradation via coa ligation.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is benzoyl-CoA:acceptor oxidoreductase. Other names in common use include:

  • 4-hydroxybenzoyl-CoA reductase (dehydroxylating), and
  • 4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase.

References

  1. Glockler R, Tschech A, Fuchs G (1989). "Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in a denitrifying, phenol-degrading Pseudomonas species". FEBS Lett. 251 (1–2): 237–40. doi:10.1016/0014-5793(89)81461-9. PMID 2753161. S2CID 34285295.
  2. Heider J, Boll M, Breese K, Breinig S, Ebenau-Jehle C, Feil U, Gad'on N, Laempe D, Leuthner B, Mohamed ME, Schneider S, Burchhardt G, Fuchs G (August 1998). "Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica". Arch. Microbiol. 170 (2): 120–31. doi:10.1007/s002030050623. PMID 9683649. S2CID 34536644.

Further reading


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