AAK1

Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the AAK1 gene[5][6][7] and is involved in clathrin mediated endocytosis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[7]

AAK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAAK1, AP2 associated kinase 1
External IDsOMIM: 616405 MGI: 1098687 HomoloGene: 128746 GeneCards: AAK1
EC number2.7.11.1
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2p13.3Start69,457,997 bp[1]
End69,674,349 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

22848

269774

Ensembl

ENSG00000115977

ENSMUSG00000057230

UniProt

Q2M2I8

Q3UHJ0

RefSeq (mRNA)

NM_014911
NM_001371575
NM_001371577

NM_001040106
NM_177762

RefSeq (protein)

NP_055726
NP_001358504
NP_001358506

NP_001035195
NP_808430
NP_001365581
NP_001365583
NP_001365584

Location (UCSC)Chr 2: 69.46 – 69.67 MbChr 6: 86.85 – 87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit endocytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000115977 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000057230 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Conner SD, Schmid SL (Mar 2002). "Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis". The Journal of Cell Biology. 156 (5): 921–9. doi:10.1083/jcb.200108123. PMC 2173317. PMID 11877461.
  6. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (Dec 2002). "The protein kinase complement of the human genome". Science. 298 (5600): 1912–34. doi:10.1126/science.1075762. PMID 12471243. S2CID 26554314.
  7. "Entrez Gene: AAK1 AP2 associated kinase 1".

Further reading

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