ACSS3

ACSS3
Identifiers
Aliases	ACSS3, acyl-CoA synthetase short-chain family member 3, acyl-CoA synthetase short chain family member 3
External IDs	OMIM: 614356 MGI: 2685720 HomoloGene: 11587 GeneCards: ACSS3
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	81,261,210 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	107,123,668 bp[2]
Gene ontology
Molecular function	• nucleotide binding; • ligase activity; • catalytic activity; • ATP binding; • acetate-CoA ligase activity;
Cellular component	• mitochondrion; • mitochondrial matrix;
Biological process	• metabolism; • ketone body biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	79611
	380660
	ENSG00000111058
	ENSMUSG00000035948
	Q9H6R3
	Q14DH7
	NM_024560; NM_001330242; NM_001330243
	NM_001142804; NM_198636
	NP_001317171; NP_001317172; NP_078836
	NP_001136276; NP_941038
	Wikidata
View/Edit Human	View/Edit Mouse

Acyl-CoA synthetase short-chain family member 3 is a protein that in humans is encoded by the ACSS3 gene.[5]

Function

ACSS3 is part of a family known as Acyl-coenzyme A synthetases (ACSs), which catalyze the initial reaction in fatty acid metabolism. This reaction activates fatty acids via thioesterification to CoA, thereby allowing their participation in both anabolic and catabolic pathways. The existence of many ACSs suggests that each plays a unique role, directing the acyl-CoA product to a specific metabolic fate. Knowing the full complement of ACS genes in the human genome will facilitate future studies to characterize their specific biological functions.[6]

References

GRCh38: Ensembl release 89: ENSG00000111058 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000035948 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Acyl-CoA synthetase short-chain family member 3".
Watkins PA, Maiguel D, Jia Z, Pevsner J (Dec 2007). "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome". Journal of Lipid Research. 48 (12): 2736–50. doi:10.1194/jlr.M700378-JLR200. PMID 17762044.

Hunter AM, Leuchter AF, Power RA, Muthén B, McGrath PJ, Lewis CM, Cook IA, Garriock HA, McGuffin P, Uher R, Hamilton SP (Sep 2013). "A genome-wide association study of a sustained pattern of antidepressant response". Journal of Psychiatric Research. 47 (9): 1157–65. doi:10.1016/j.jpsychires.2013.05.002. PMC 3710535. PMID 23726668.
Watkins PA, Maiguel D, Jia Z, Pevsner J (Dec 2007). "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome". Journal of Lipid Research. 48 (12): 2736–50. doi:10.1194/jlr.M700378-JLR200. PMID 17762044.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000111058 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035948 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Acyl-CoA synthetase short-chain family member 3".

[6] Watkins PA, Maiguel D, Jia Z, Pevsner J (Dec 2007). "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome". Journal of Lipid Research. 48 (12): 2736–50. doi:10.1194/jlr.M700378-JLR200. PMID 17762044.

Enzymes: CO CS and CN ligases (EC 6.1-6.3)
6.1: Carbon-Oxygen	Aminoacyl tRNA synthetase Alanine Arginine Asparagine Aspartate Cysteine D-alanine—poly(phosphoribitol) ligase Glutamate Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine
6.2: Carbon-Sulfur	Succinyl coenzyme A synthetase Acetyl—CoA synthetase Long-chain-fatty-acid—CoA ligase
6.3: Carbon-Nitrogen	Glutamine synthetase Ubiquitin ligase Cullin Von Hippel–Lindau tumor suppressor UBE3A Mdm2 Anaphase-promoting complex UBR1 Glutathione synthetase CTP synthetase Adenylosuccinate synthase Argininosuccinate synthase Holocarboxylase synthetase GMP synthase Asparagine synthetase Carbamoyl phosphate synthetase I II Glutamate–cysteine ligase

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

ACSS3

Function

References

Further reading