ANAPC10

Anaphase-promoting complex subunit 10 is an enzyme that in humans is encoded by the ANAPC10 gene.[5][6][7]

ANAPC10
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesANAPC10, APC10, DOC1, anaphase promoting complex subunit 10
External IDsOMIM: 613745 MGI: 1916249 HomoloGene: 32238 GeneCards: ANAPC10
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q31.21Start144,831,908 bp[1]
End145,098,541 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10393

68999

Ensembl

ENSG00000164162

ENSMUSG00000036977

UniProt

Q9UM13

Q8K2H6

RefSeq (mRNA)

NM_026904
NM_001357234
NM_001357235
NM_001357236
NM_001357237

RefSeq (protein)

NP_081180
NP_001344163
NP_001344164
NP_001344165
NP_001344166

Location (UCSC)Chr 4: 144.83 – 145.1 MbChr 8: 79.71 – 79.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

ANAPC10 has been shown to interact with CDC27,[8][9] Mothers against decapentaplegic homolog 3[10] and Mothers against decapentaplegic homolog 2.[10]

References

  1. GRCh38: Ensembl release 89: ENSG00000164162 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000036977 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM (May 1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". The Journal of Biological Chemistry. 274 (20): 14500–7. doi:10.1074/jbc.274.20.14500. PMID 10318877.
  6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  7. "Entrez Gene: ANAPC10 anaphase promoting complex subunit 10".
  8. Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.
  9. Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
  10. Nourry C, Maksumova L, Pang M, Liu X, Wang T (May 2004). "Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1". BMC Cell Biology. 5: 20. doi:10.1186/1471-2121-5-20. PMC 420458. PMID 15144564.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.