ANAPC5

Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.[5][6]

ANAPC5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesANAPC5, APC5, anaphase promoting complex subunit 5
External IDsOMIM: 606948 MGI: 1929722 HomoloGene: 41118 GeneCards: ANAPC5
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q24.31Start121,308,245 bp[1]
End121,399,896 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

51433

59008

Ensembl

ENSG00000089053

ENSMUSG00000029472

UniProt

Q9UJX4

Q8BTZ4

RefSeq (mRNA)

NM_001137559
NM_016237
NM_001330489

RefSeq (protein)

NP_001131031
NP_001317418
NP_057321

Location (UCSC)Chr 12: 121.31 – 121.4 MbChr 5: 122.79 – 122.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The anaphase-promoting complex (APC) consists of at least 8 protein subunits, including APC5, CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; MIM 603462).[supplied by OMIM][6]

Interactions

ANAPC5 has been shown to interact with ANAPC1,[7][8] ANAPC4,[7] CDC27[7][9][10] and PABPC1.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000089053 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029472 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (March 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354): 1219–22. Bibcode:1998Sci...279.1219Y. doi:10.1126/science.279.5354.1219. PMID 9469815.
  6. "Entrez Gene: ANAPC5 anaphase promoting complex subunit 5".
  7. Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947. S2CID 5942532.
  8. Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961.
  9. Koloteva-Levine, Nadejda; Pinchasi, Dalia; Pereman, Idan; Zur, Amit; Brandeis, Michael; Elroy-Stein, Orna (May 2004). "The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal Ribosome Entry Site-Mediated Translation". Mol. Cell. Biol. 24 (9): 3577–87. doi:10.1128/MCB.24.9.3577-3587.2004. ISSN 0270-7306. PMC 387753. PMID 15082755.
  10. Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. ISSN 0027-8424. PMC 16806. PMID 10922056.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.