AP1M1

AP-1 complex subunit mu-1 is a protein that in humans is encoded by the AP1M1 gene.[5][6]

AP1M1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAP1M1, AP47, CLAPM2, CLTNM, MU-1A, adaptor related protein complex 1 mu 1 subunit, adaptor related protein complex 1 subunit mu 1
External IDsOMIM: 603535 MGI: 102776 HomoloGene: 4017 GeneCards: AP1M1
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.11Start16,197,578 bp[1]
End16,245,907 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8907

11767

Ensembl

ENSG00000072958

ENSMUSG00000003033

UniProt

Q9BXS5

P35585

RefSeq (mRNA)

NM_001130524
NM_032493

NM_007456

RefSeq (protein)

NP_001123996
NP_115882

NP_031482

Location (UCSC)Chr 19: 16.2 – 16.25 MbChr 8: 72.24 – 72.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing.[7]

Interactions

AP1M1 has been shown to interact with VAMP4[8] and AP1G1.[9][10]

References

  1. GRCh38: Ensembl release 89: ENSG00000072958 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003033 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Peyrard M, Parveneh S, Lagercrantz S, Ekman M, Fransson I, Sahlén S, Dumanski JP (Jun 1998). "Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG)". Genomics. 50 (2): 275–80. doi:10.1006/geno.1998.5289. PMID 9653655.
  6. Medigeshi GR, Krikunova M, Radhakrishnan K, Wenzel D, Klingauf J, Schu P (Jan 2008). "AP-1 membrane-cytoplasm recycling regulated by mu1A-adaptin". Traffic. 9 (1): 121–32. doi:10.1111/j.1600-0854.2007.00672.x. PMID 17988225.
  7. "Entrez Gene: AP1M1 adaptor-related protein complex 1, mu 1 subunit".
  8. Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA (Dec 2003). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1". EMBO Reports. 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. PMC 1326413. PMID 14608369.
  9. Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell. 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. PMID 10535737. S2CID 15288582.
  10. Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal of Cell Biology. 131 (3): 619–30. doi:10.1083/jcb.131.3.619. PMC 2120623. PMID 7593184.

Further reading


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