AP1M2

AP-1 complex subunit mu-2 is a protein that in humans is encoded by the AP1M2 gene.[5][6]

AP1M2
Identifiers
AliasesAP1M2, AP1-mu2, HSMU1B, MU-1B, MU1B, mu2, adaptor related protein complex 1 mu 2 subunit, adaptor related protein complex 1 subunit mu 2
External IDsOMIM: 607309 MGI: 1336974 HomoloGene: 55906 GeneCards: AP1M2
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.2Start10,572,671 bp[1]
End10,587,315 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10053

11768

Ensembl

ENSG00000129354

ENSMUSG00000003309

UniProt

Q9Y6Q5

Q9WVP1

RefSeq (mRNA)

NM_001300887
NM_005498

NM_001110300
NM_009678

RefSeq (protein)

NP_001287816
NP_005489

NP_001103770
NP_033808

Location (UCSC)Chr 19: 10.57 – 10.59 MbChr 9: 21.29 – 21.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a subunit of the heterotetrameric adaptor-related protein complex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals.[6]

Interactions

AP1M2 has been shown to interact with AP2B1.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000129354 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000003309 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ohno H, Tomemori T, Nakatsu F, Okazaki Y, Aguilar RC, Foelsch H, Mellman I, Saito T, Shirasawa T, Bonifacino JS (Apr 1999). "Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells". FEBS Letters. 449 (2–3): 215–20. doi:10.1016/S0014-5793(99)00432-9. PMID 10338135. S2CID 82686795.
  6. "Entrez Gene: AP1M2 adaptor-related protein complex 1, mu 2 subunit".
  7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.