Achilleol B synthase

Achilleol B synthase (EC 5.4.99.48) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, achilleol-B-forming).[1] This enzyme catalyses the following chemical reaction

(3S)-2,3-epoxy-2,3-dihydrosqualene achilleol B
Achilleol B synthase
Identifiers
EC number5.4.99.48
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Achilleol B is probably formed by cleavage of the 8-14 and 9-10 bonds of (3S)-2,3-epoxy-2,3-dihydrosqualene.

References

  1. Ito R, Mori K, Hashimoto I, Nakano C, Sato T, Hoshino T (May 2011). "Triterpene cyclases from Oryza sativa L.: cycloartenol, parkeol and achilleol B synthases". Organic Letters. 13 (10): 2678–81. doi:10.1021/ol200777d. PMID 21526825.
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