Adhuri Kahaani Hamari

• Laksh Lalwani as Yuvraj Madhav / Krish[1]
• Mahima Makwana as Manasvini "Manu " (Devrakshika) / Radhika[1]

• Suhani Dhanki as Maya, an evil naagin
• Nitin Sahrawat as Raja Lakshman Dev
• Amrapali Gupta as Anamika, Queen of Naag vansh, Bade Raja's lover[2]
• Gajendra Chauhan as Bade Raja, Madhav's father
• Pragati Mehra as Maithali, Badi Rani, Madhav's mother
• Nitin Sahrawat as Chhote Raja, Bade Raja's younger brother
• Preet Kaur Madhan as Chotti Rani, Chhote Raja's wife
• Shubhangi Atre Poorey as Devsena, Manasvini's aunt, former Devrakshika
• Juhi Aslam as Takshika, Maya's assistant, head of the ichhadhaari naags

• Himani Shivpuri as Radhika's aunt
• Nupur Alankar as Krish's mother
• Unknown as Balvinder, Krish's uncle
• Dolly Minhas as Pammi, Balvinder's wife
• Love Kwatra as Om, Krish's elder brother
• Unknown as Mehak, Krish's sister
• Kashvi Kothari as Tulsi, a young naagin who later transfers her power to Radhika
• Nisha Nagpal as Avni, Mehak's friend
• Ronit Chauhan as Purushharth, Balvinder and Pammi's son, Avni's husband
• Unknown as Baba Gorakdas, a snake charmer and helps Preeti in assassinating Radhika
• Pratyusha Banerjee as Naagin (Cameo appearance in song)[3]
• Rashami Desai as Preeti, Krish's sister-in-law and a daayan[4][5] (Cameo Role)
• Deepshikha Nagpal as Daayani, Preeti's evil sister

There were rumors that Mahima slapped Laksh during a rehearsal of &TV holi event. However, later on in an interview laksh clarified the rumors and said:

The issue has been blown out of proportion. It was a trivial argument, which often happens between any two co-actors. I didn't react when she excitedly applied colors on me during a media interaction at the Holi event as I realize it was unintentional on her part.[6]

After the holi incident there were news of Mahima being replaced by Sanjeeda Sheikh or Sara Khan from the show. Nevertheless, She continued in the show. In an interview with tellychakkar.com she said:

Yes, the Producer Gul Khan personally met me and we cleared things.[7]

In March 2016 an intimate scene was being to be shot between Laksh aka Krish and Mahima aka Radhika. However, Mahima denied to do it. During a press interview, She said:

Yes I refused to do the scene because I felt it was too intimate. My mother's presence has got nothing to do with my refusal to shoot. I am very young to film such sequences. Hence I had reservations. Even if my mother wasn't present, I would not have done it because I felt it was too much. I had a word with my director and explained to him my discomfort would be visible in the scene too. I told him to tone it down to a level where I could be comfortable filming it. I did not want the show to suffer and had no intentions of inconveniencing those involved. I readily shot when they made the changes.[8]

In November 2015, Mahima got injured on the set while shooting for a prominent jail sequence, wherein she had to run away breaking the chains. However, she ended up injuring her head while shooting for it. Nevertheless, she continued to shoot and completed her scene. Later on, people on the sets panicked and took her to the doctor to get the CT scan done [9].During a press interview she said:

I was very excited, as I got the opportunity to perform an act like Deepika Padukone from "Bajirao Mastani". During the last shot I had to twirl the chain and when I pulled the chain from both the sides it came falling on my head and I was injured badly.[10]

Again in March 2017, Nupur Alankar got injured while shooting for a death sequence.[11]