Aline Miller

Miller studied Chemistry at the University of Strathclyde and graduated in 1997.[2] She was an undergraduate exchange student at Franklin & Marshall College.[2] Miller joined Durham University as a post graduate student, earning a PhD in 2000 under the supervision of Randal Richards.[2] Miller worked on graft copolymers, which included polynorbornene and polyethylene oxide, and studied their organisation at air-water interfaces.[1] After completing her doctorate, Miller moved to New Hall College at the University of Cambridge, where she was appointed a Junior Research Fellow and she worked with Athene Donald on cellulose.[3][4][5][6] She was inspired to have a career in research during this fellowship.[7]

Miller joined the University of Manchester Institute of Science and Technology (UMIST) in 2002.[8] She was made a full Professor in 2014.[2] She currently works in CEAS - Academic & Research Department of Chemical Engineering & Analytical Science at the Manchester Institute of Biotechnology. She investigates the behaviour of molecules at different interfaces, including the air-liquid and liquid-liquid interface. Surfactants and polymers can be used to promote or inhibit the crystallisation of small molecules, for example the use of hydroxyl based polymers in the crystallisation of ice cream. To mimic how fish use macromolecules to stop their blood freezing, Miller combines antifreeze proteins with ice crystals.[8] In 2004 Miller established the University of Manchester Polymers & Peptides Research Group.[3] Here she works on the characterisation of polymer, biopolymer and peptides, using neutron and x-ray scattering. The in-depth characterisation of these materials allows Miller to tailor them for specific applications.[8]

Miller also works in biomedical engineering, creating three-dimensional scaffolds through the control of proteins and peptides.[8][9] She explores the relationship between mesoscopic structure, material properties and cell response.[10][11] She has studied how proteins self-assemble, including what causes them to unfold and form fibril structures.[12][13][14] The morphology (roughness, porosity) and mechanical properties (such as Young's modulus and viscosity) can be controlled through self-assembly.[3] The self-assembling peptides can be conjugated with polymers that are sensitive to pH and temperature. Through the synthesis of short peptides with various amino acid sequences the Miller group are studying the self-assembly of Beta sheets.[15] She has developed a biocompatible, biodegradable cardiac patch, created from a thick porous scaffold coated with a material that mimics the extracellular matrix.[16] She also studies the degradation mechanism of these materials.[17]

Miller was awarded a small grant from the University of Manchester to develop the synthesis of peptide-based hydrogels.[18] The synthetic peptide hydrogels were so successful that she set up the spin-out company PeptiGelDesign, a group which worked to commercialise hydrogel technologies.[19] Since 2008 PeptiGelDesign have raised over £6 million in funding.[19] Recognising the reach and potential of PeptiGelDesign, the company relaunched as Manchester BIOGEL in 2018, continuing to offer peptide-based hydrogels amongst other biomaterials.[20] The hydrogels can be used to improve the quality of drug toxicity testing, DNA sensing and regenerative medicine.[20][21]

• Aline Miller publications indexed by Google Scholar