Alpha-L-fucosidase

In enzymology, an alpha-L-fucosidase (EC 3.2.1.51) is an enzyme that catalyzes the chemical reaction

an alpha-L-fucoside + H2O L-fucose + an alcohol
Alpha-L-fucosidase
crystal structure of thermotoga maritima alpha-fucosidase
Identifiers
SymbolAlpha_L_fucos
PfamPF01120
Pfam clanCL0058
InterProIPR000933
PROSITEPDOC00324
SCOP21hl9 / SCOPe / SUPFAM
CAZyGH29
alpha-L-fucosidase
Identifiers
EC number3.2.1.51
CAS number9037-65-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are alpha-L-fucoside and H2O, whereas its two products are L-fucose and alcohol.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is alpha-L-fucoside fucohydrolase. This enzyme is also called alpha-fucosidase. This enzyme participates in n-glycan degradation and glycan structures - degradation.

Deficiency of this enzyme is called Fucosidosis.

In CAZy, alpha-L-fucosidases are found in glycoside hydrolase family 29 and glycoside hydrolase family 95.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1HL8, 1HL9, and 1ODU.

Human medical studies

It was in a recent study by Endreffy, Bjørklund and collaborators (2017) found an association between the activity of α-L-fucosidase-1 (FUCA-1) and chronic autoimmune disorders in children.[1] This should encourage further research on FUCA-1 as a marker of chronic inflammation and autoimmunity.

See also

References

  1. Endreffy I, Bjørklund G, Szerafin L, Urbina MA, Chirumbolo S, Endreffy E. Plasma alpha-L-fucosidase activity in chronic inflammation and autoimmune disorders in a pediatric cohort of hospitalized patients. Immunologic Research 2017. doi: 10.1007/s12026-017-8943-x.

Further reading

  • Levvy GA, Mcallan A (August 1961). "Mammalian fucosidases. 2. alpha-L-Fucosidase". The Biochemical Journal. 80 (2): 435–9. doi:10.1042/bj0800435. PMC 1244021. PMID 13761578.
  • Reglero A, Cabezas JA (July 1976). "Glycosidases of molluscs. Purification and properties of alpha-L-fucosidase from Chamelea gallina L". European Journal of Biochemistry / FEBS. 66 (2): 379–87. doi:10.1111/j.1432-1033.1976.tb10527.x. PMID 7458.
  • Tanaka K, Nakano T, Noguchi S, Pigman W (August 1968). "Purification of alpha-L-fucosidase of abalone livers". Archives of Biochemistry and Biophysics. 126 (2): 624–33. doi:10.1016/0003-9861(68)90449-9. PMID 5672520.


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