Amine oxidase

An amine oxidase is an enzyme that catalyzes the oxidative cleavage of alkylamines into aldehydes and ammonia:[1]

RCH2NH2 + H2O + O2 RCHO + NH3 + H2O2

Amine oxidases are divided into two subfamilies based on the cofactor they contain:

ClassCofactorSubclassEnzyme Commission numberHuman genes
Amine oxidase
(formerly EC 1.4.3.6)
copperlysyl oxidaseEC 1.4.3.13LOX
primary-amine oxidaseEC 1.4.3.21AOC2, AOC3
diamine oxidaseEC 1.4.3.22AOC1
Monoamine oxidaseflavinN/AEC 1.4.3.4MAOA, MAOB

References

  1. Mondovì B, Finazzi Agrò A (1982). "Structure and function of amine oxidase". Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Bioligy. 148: 141–53. doi:10.1007/978-1-4615-9281-5_12. ISBN 978-1-4615-9283-9. PMID 7124512.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.