Annie McNamara

Annie first appears on the show in the pilot episode. Here she is shown as going back to school, allowing her mother Julia to go back to medical school. She also adopts the class pet gerbil, Frisky. Julia later kills the pet but does not tell Annie, buying a new one.

In Season 2, Annie, at the age of 8, starts puberty. Annie's friend's mother throws Annie a "Princess Menses" party and invites her friends to celebrate the passage to womanhood.

In Season 3 Annie has to talk to Family Services about her father Sean's anger problem. She leads them to believe, unintentionally, that he may be physically abusive and that he has emotionally affected her. She is briefly taken away from Sean until further notice. She is then put to stay with Julia.

In season 4 Annie learns her mother is going to give birth to a boy with syndactyly, a webbing of the fingers and toes. Annie, in a sincere attempt to understand this birth defect, tapes her fingers together to understand how her brother would feel and alters her doll hands to have the same appearance. Sean and Julia interpret this as mockery, and Julia forces Annie to throw out her modified toys which she finds offensive. Julia gives birth to a boy, Conor, and Annie is uncomfortable with him because of his handicap. She is taken away by her mother when Julia leaves for New York City towards the end of the season.

In Season 5, Annie is living with Julia, her new girlfriend Olivia Lord, and her sociopathic daughter Eden. Eden, under the guise of being a caring "older sister", encourages Annie to lose weight to attract the attention of a boy she likes. She even asks Sean to perform liposuction on her, but he forbids it. After a failed attempt at inducing bulimia, Eden encourages Annie to move onto "Plan C"; the next day Sean gets a call from Julia saying Annie has been expelled from her school for being caught performing fellatio on the boy she has a crush on. Sean, knowing Eden put her up to it, threatens Eden to stay away from her and him. In the final episode of the season, Annie is seriously hurt by a car crash with Sean's friend Christian Troy when they are trying to escape the paparazzi. She is being operated on by Sean in the last scene.

In Season 6, Annie is now a teenager and is openly resentful against her parents after their separation. Things are made worse after Sean abruptly marries Teddy. During a visit with her father, Sean discovers that Annie has been pulling her hair out and ingesting it (a stress reaction known as "Rapunzel Syndrome"). Annie suffers a severe abdominal cramp due to the ingested hair and underwent surgery to remove it. Soon afterwards Sean decided to double his life insurance policy and made Annie and Connor the sole beneficiaries (Matt was not included because he wasted the money Sean gave him from selling his house in Miami). Teddy attempts to kill Annie, Connor, and Sean in order to get the insurance money, but fails.