Antibody-oligonucleotide conjugate

Antibody-oligonucleotide conjugates or AOCs belong to a class of chimeric molecules combining in their structure two important families of biomolecules: monoclonal antibodies and oligonucleotides.[1]

Schematic structure of an antibody-oligonucleotide conjugate (AOC)

Combination of exceptional targeting capabilities of monoclonal antibodies with numerous functional modalities of oligonucleotides has been fruitful for a variety of applications with AOC including imaging, detection and targeted therapeutics.[1][2][3]

See also

References
  1. Dovgan, Igor; Koniev, Oleksandr; Kolodych, Sergii; Wagner, Alain (2019). "Antibody–Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents". Bioconjugate Chemistry. 30 (10): 2483–2501. doi:10.1021/acs.bioconjchem.9b00306. ISSN 1043-1802. PMID 31339691.
  2. Levin, Arthur A. (2017). "Targeting Therapeutic Oligonucleotides". New England Journal of Medicine. Massachusetts Medical Society. 376 (1): 86–88. doi:10.1056/nejmcibr1613559. ISSN 0028-4793. PMID 28052219.
  3. Winkler, Johannes (2013). "Oligonucleotide conjugates for therapeutic applications". Therapeutic Delivery. Future Science Ltd. 4 (7): 791–809. doi:10.4155/tde.13.47. ISSN 2041-5990.
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