Artificially Expanded Genetic Information System

Artificially Expanded Genetic Information System (AEGIS) is a synthetic DNA analog experiment that uses some unnatural base pairs from the laboratories of the Foundation for Applied Molecular Evolution in Gainesville, Florida. AEGIS is a NASA-funded project to try to understand how extraterrestrial life may have developed.[1]

The system uses twelve different nucleobases in its genetic code. These include the four canonical nucleobases found in DNA (adenine, cytosine, guanine and thymine) plus eight synthetic nucleobases).[2][3][4][5][1] AEGIS includes S:B, Z:P, V:J and K:X base pairs.[6]

See also

References
  1. Lloyd, Robin (February 14, 2009). "New Artificial DNA Points to Alien Life". LiveScience. Retrieved 5 July 2016.
  2. Yang, Z.; Hutter, D.; Sheng, P.; Sismour, A. M.; Benner, S. A. (29 October 2006). "Artificially expanded genetic information system: a new base pair with an alternative hydrogen bonding pattern". Nucleic Acids Research. 34 (21): 6095–6101. doi:10.1093/nar/gkl633. PMC 1635279. PMID 17074747. Retrieved 5 July 2016.
  3. Benner, SA; Hutter, D; Sismour, AM (1 September 2003). "Synthetic biology with artificially expanded genetic information systems. From personalized medicine to extraterrestrial life". Nucleic Acids Research. Supplement. 3 (3): 125–6. doi:10.1093/nass/3.1.125. PMID 14510412. Retrieved 5 July 2016.
  4. Benner, Steven A. (December 2010). "Defining Life". Astrobiology. 10 (10): 1021–1030. Bibcode:2010AsBio..10.1021B. doi:10.1089/ast.2010.0524. PMC 3005285. PMID 21162682.
  5. Klotz, Irene (February 27, 2009). "Synthetic life form grows in Florida lab". Science. Retrieved 5 July 2016.
  6. Bradley, K. M.; Benner, S. A. (2014). "OligArch: A software tool to allow artificially expanded genetic information systems (AEGIS) to guide the autonomous self-assembly of long DNA constructs from multiple DNA single strands". Beilstein Journal of Organic Chemistry. 10: 1826–1833. doi:10.3762/bjoc.10.192. PMC 4142867. PMID 25161743.
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