BACE1-AS

BACE1-AS, also known as BACE1 antisense RNA (non-protein coding), is a human gene at 11q23.3 encoding a long noncoding RNA molecule. It is transcribed from the opposite strand to BACE1 and is upregulated in patients with Alzheimer's disease.[2] BACE1-AS regulates the expression of BACE1 by increasing BACE1 mRNA stability and generating additional BACE1 through a post-transcriptional feed-forward mechanism. By the same mechanism it also raises concentrations of beta amyloid, the main constituent of senile plaques. BACE1-AS concentrations are elevated in subjects with Alzheimer's disease and in amyloid precursor protein transgenic mice.

BACE1-AS
Identifiers
AliasesBACE1-AS, BACE1 antisense RNA, BACE1-AS1, FJ573250, NCRNA00177
External IDsOMIM: 614263 GeneCards: BACE1-AS
Orthologs
SpeciesHumanMouse
Entrez

100379571

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Ensembl

ENSG00000278768

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

Knocking down BACE1-AS reduces amyloid production and plaque deposition.[3]

References
  1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, Finch CE, St Laurent G, Kenny PJ, Wahlestedt C (2008). "Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase". Nat Med. 14 (7): 723–730. doi:10.1038/nm1784. PMC 2826895. PMID 18587408.
  3. Modarresi F, Faghihi MA, Patel NS, Sahagan BG, Wahlestedt C, Lopez-Toledano MA (2011). "Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis". Int. J. Alzheimer's Dis. 2011: 929042. doi:10.4061/2011/929042. PMC 3139208. PMID 21785702.
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