BAH domain

In molecular biology, the BAH domain (bromo-adjacent homology) domain is found in proteins such as eukaryotic DNA (cytosine-5) methyltransferases, the origin recognition complex 1 (Orc1) proteins, Bromo adjacent homology domain containing 1 (BAHD1), as well as several proteins involved in transcriptional regulation. The BAH domain appears to act as a protein-protein interaction module specialised in gene silencing, as suggested for example by its interaction within yeast Orc1p with the silent information regulator Sir1p. The BAH domain might therefore play an important role by linking DNA methylation, replication and transcriptional regulation.[1]

BAH
crystal structure of the n-terminal bah domain of orc1p
Identifiers
SymbolBAH
PfamPF01426
InterProIPR001025
MEROPSC89
SCOP21m4z / SCOPe / SUPFAM
CDDcd04370

References

This article incorporates text from the public domain Pfam and InterPro: IPR001025
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