Benzamidenafil

Benzamidenafil or xanthoanthrafil is a synthetic drug that acts as a PDE5 inhibitor. It has the same mechanism of action as pharmaceutical drugs used to treat erectile dysfunction, but it is not approved by any regulatory agency for such use.[1] It has been found as an undeclared adulterant in supposedly "natural" health supplements.[1][2] In 2009, the supplement manufacturer Hi-Tech Pharmaceuticals recalled its product Stamina-Rx because it was adulterated with benzamidenafil.[3]

Benzamidenafil
Names
IUPAC name
N-[(3,4-Dimethoxyphenyl)methyl]-2-(1-hydroxypropan-2-ylamino)-5-nitrobenzamide
Other names
Xanthoanthrafil
Identifiers
3D model (JSmol)
ChemSpider
MeSH C442640
UNII
Properties
C19H23N3O6
Molar mass 389.408 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References

  1. Rica Lewis (Aug 16, 2013). "Stamina Rx Ingredients".
  2. Zou, Peng; Hou, Peiling; Oh, Sharon Sze-Yin; Ge, Xiaowei; Bloodworth, Bosco Chen; Low, Min-Yong; Koh, Hwee-Ling (2008). "Identification of benzamidenafil, a new class of phosphodiesterase-5 inhibitor, as an adulterant in a dietary supplement". Journal of Pharmaceutical and Biomedical Analysis. 47 (2): 255–259. doi:10.1016/j.jpba.2008.01.004. PMID 18280079.
  3. "FDA MedWatch – Stamina-Rx Dietary Supplement Products". Vanderbuilt University. Archived from the original on 2016-03-04. Retrieved 2014-09-14.


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