Beta-Lactamase Database (BLAD)

Beta-Lactamase Database (BLAD)
Content
Description	The Beta-Lactamase Database (BLAD) provides 3D structural information specifically on beta-lactamases and is updated regularly.
Data types; captured	Beta-lactamase
Organisms	Bacteria
Contact
Research center	Aligarh Muslim University
Primary citation	PMID 23943635
Access
Website	BLAD
Miscellaneous
Bookmarkable; entities	yes

The Beta-Lactamase Database (BLAD) is a web-based antimicrobial resistance database that provides structural and phenotypic data on a class of enzymes, beta-lactamase.[1] It hosts sequences from all classes of metallo and non-metallo beta-lactamases. The resource has approximately 2000 gene sequences and compiles its data from various literature, NCBI, protein data bank [2] and other mediums. BLAD is based at the Aligarh Muslim University in the Interdisciplinary Biotechnology Unit. BLAD has four search fields on their site: database, resistance, PDBS, and genome.

When looking at their database tab, users are able to see NCBI cross-linked information about sequences, specifically looking at nucleotides and proteins. This data can also be exported for the entry of interest. Under the resistance tab, information about beta-lactamases that confer resistance to antimicrobial drugs is available. PDBS, or Protein Data Bank file formatting, has three-dimensional structural information on beta-lactamases, their variants, and associated ligands. Lastly, the genome tab provides information of the plasmids that contain the beta-lactamase gene and identifying characteristics.

References

Danishuddin, M.; Hassan Baig, M.; Kaushal, L.; Khan, A. U. (2013). "BLAD: A comprehensive database of widely circulated beta-lactamases". Bioinformatics. 29 (19): 2515–2516. doi:10.1093/bioinformatics/btt417.
Sussman, Joel L.; Lin, Dawei; Jiang, Jiansheng; Manning, Nancy O.; Prilusky, Jaime; Ritter, Otto; Abola, Enrique E. (1998). "Protein Data Bank (PDB): Database of Three-Dimensional Structural Information of Biological Macromolecules". Acta Crystallographica Section D. 54 (6): 1078–1084. doi:10.1107/s0907444998009378.

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[1] Danishuddin, M.; Hassan Baig, M.; Kaushal, L.; Khan, A. U. (2013). "BLAD: A comprehensive database of widely circulated beta-lactamases". Bioinformatics. 29 (19): 2515–2516. doi:10.1093/bioinformatics/btt417.

[2] Sussman, Joel L.; Lin, Dawei; Jiang, Jiansheng; Manning, Nancy O.; Prilusky, Jaime; Ritter, Otto; Abola, Enrique E. (1998). "Protein Data Bank (PDB): Database of Three-Dimensional Structural Information of Biological Macromolecules". Acta Crystallographica Section D. 54 (6): 1078–1084. doi:10.1107/s0907444998009378.