Big Nate: In the Zone

• Big Nate: In a Class By Himself
• Big Nate: Strikes Again
• Big Nate: On a Roll
• Big Nate Goes for Broke
• Big Nate: Flips Out
• Big Nate: In the Zone
• Big Nate: Lives It Up
• Big Nate: Blasts Off

Nate is being yelled at by Principal Nichols because Teddy accidentally destroyed his War of 1812 outline. Nate then sarcastically states that his life is great, then gives a dramatic flashback of the day before, how Teddy turned his outline into a "soggy, syrupy pile of confetti," as he calls it. During the past week, he has had a terrible case of bad luck, including failing grades, cavities, and being easily made fun of. Later, after Nate fails to turn in his outline, he is tasked with completing another one.

After finishing, he notices his crush, Jenny, and her boyfriend, Artur, who are rather obnoxiously displaying love. An envious Nate then makes a list of horrible pet names that he feels Artur should be called, including "Fart Bucket," "Nate Wanna-be," and "Soon-to-be former boyfriend." Chad appears and notices Nate. After being asked what he was working on, Nate lies quickly and says he was about to start an "Ultra-Nate" comic. Chad requests to also starr. Chad, who has a crush on Maya, asks Nate if she could be saved by him. Nate finishes the comic and is prompted by Chad to start thinking about life with superpowers.

The bad luck, however makes Nate suppose he could theoretically simulate landing after flying. Nate jumps off a table and on to a beanbag, bursting it wide open. Nate is then yelled at for the third time of the day. Nate and Chad are given detention and asked to fix the beanbag chair. While fixing it, the home economics teacher, Mrs. Brindle, mentions a "fitness zone." After they are done, they notice that due to the new program, all the snacks in the vending machine have gone completely healthy. Their friend, Dee Dee, shows up and says that Nate has to report to the principal's office. Nate arrives and is greeted by Nichols. Nichols states that the fitness zone needs to be welcomed in a popular way: music. Nichols then asks Nate to create a song out of the rules of the fitness zone. Nichols also cancels Nate and Chad's detentions, due to the fact that Nate and Chad have a role in their band, Enslave The Mollusk.

After school, ETM (Enslave The Mollusk) creates a rock anthem called "You're Never Alone In The Fitness Zone," key of C. When Artur is assigned to take the rules and convert them to lyrics, Nate's terrible luck causes Artur to notice the list of pet names, resulting in him quitting out of embarrassment. Without a lead singer, ETM has to choose between Nate, Francis (both have "natural disasters" for voices) and Teddy (not skilled enough to sing and play at the same time). They choose on Nate, him having an edge over Francis. The next day, Nate comes down with nerves and forgets the lyrics, making ETM a laughingstock, especially teased by a popular 7th-grader named Marcus Goode. The next week, report cards get sent home, Nate with a D in Social Studies, all other Bs, plus an A in art. He is then given a lucky foot charm by Chad, which he refers to as "the Foot." Immediately, good luck happens everywhere in Nate's life. He is able to shoot a hoop that barely touches the net from mid-court, backwards, and with his eyes closed, a math test is postponed, a free period is given to Nate, and he is given $20 by some lady, all because he found her necklace in the grass.

Unfortunately, Maya is shown to be going out with Marcus. Later, Nate's Dad gives him a punishment of no drawing comics before bed. Nate loopholes around this and draws on his sneakers. The stylized sneakers make him more popular than Marcus, causing Marcus to be very envious of Nate. Over the next week, Nate becomes "in the zone". He is asked to sign other kids' sneakers, his punishment is canceled, he is the MVP of back-to-back shutouts in soccer, and gets perfect scores on all his tests. However, he realizes is becoming like Artur. Nate mentally digresses and asks Artur to rejoin ETM. After successfully inviting Artur back, Coach Calhoun tells them about field day. Marcus and Maya appear and Marcus makes a bet that 6th-grade will not win a single event on Field Day as well as calling Chad "Superchunk." Maya steps up and tells Marcus to stop, stating "What's he ever done to you!?" then breaking up with Marcus. Nate then gives the Foot to Chad so he can try to hook up with a remorseful Maya.

However, the luck stops, as in a turn of events, the Foot ends up in Mrs. Godfrey's desk. On Field Day, the 6th-graders are given the sports they are the worst at. Nate has to do hurdles. Though able to gain a head start, he trips over the last hurdle, causing his competitor, Kareem Trillin, to win. The last sport is the three-legged race. Nate and Artur team up to make sure that Chad and Maya are a team. Soon, because Marcus and his partner, Jakob, do not work together, while Maya and Chad do, Nate wins the bet. The next week, an assembly is announced to give ETM a second chance. Before playing, Nate reveals that if he lost the bet, it would be a nightmare-- he would become a mini Marcus for a week. He states that Marcus is about to be defamed. The song is a success, and Marcus is embarrassed in front of the school with Chad hitting Marcus' head with a bottle-- all without the lucky foot.

• Nate Wright: a rebellious 6th-grader and the main protagonist.
• Chad Applewhite: a friend of Nate and one of Nate’s good friends.
• Marcus Goode: a bully 7th-grader and the main antagonist.
• Teddy Ortiz: a best friend of Nate.
• Maya: the love interest of Chad.
• Artur Pashkov: the singer of ETM and Jenny's exchange student boyfriend.
• Francis Pope: Nate's best friend.
• Jenny Jenkins: Artur's girlfriend and the girl whom Nate has a crush on, though she finds Nate to be completely annoying and bothering.