Bip internal ribosome entry site (IRES)

The BiP internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of BiP protein and allows cap-independent translation. BiP protein expression has been found to be significantly enhanced by the heat shock response due to internal ribosome entry site (IRES)-dependent translation. It is thought that this translational mechanism is essential for the survival of cells under stress.[1]

bip internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_Bip
Identifiers
SymbolIRES_Bip
Alt. SymbolsBip_IRES
RfamRF00223
Other data
RNA typeCis-reg; IRES
Domain(s)Eukaryota
GOGO:0043022
SOSO:0000243
PDB structuresPDBe

References

  1. Kim YK, Jang SK (September 2002). "Continuous heat shock enhances translational initiation directed by internal ribosomal entry site". Biochemical and Biophysical Research Communications. 297 (2): 224–231. doi:10.1016/S0006-291X(02)02154-X. PMID 12237106.
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