Bip internal ribosome entry site (IRES)

bip internal ribosome entry site (IRES)
	Predicted secondary structure and sequence conservation of IRES_Bip
Identifiers
Symbol	IRES_Bip
Alt. Symbols	Bip_IRES
Rfam	RF00223
Other data
RNA type	Cis-reg; IRES
Domain(s)	Eukaryota
GO	GO:0043022
SO	SO:0000243
PDB structures	PDBe

The BiP internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of BiP protein and allows cap-independent translation. BiP protein expression has been found to be significantly enhanced by the heat shock response due to internal ribosome entry site (IRES)-dependent translation. It is thought that this translational mechanism is essential for the survival of cells under stress.[1]

References

Kim YK, Jang SK (September 2002). "Continuous heat shock enhances translational initiation directed by internal ribosomal entry site". Biochemical and Biophysical Research Communications. 297 (2): 224–231. doi:10.1016/S0006-291X(02)02154-X. PMID 12237106.

External links

Page for bip internal ribosome entry site (IRES) at Rfam

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[1] Kim YK, Jang SK (September 2002). "Continuous heat shock enhances translational initiation directed by internal ribosomal entry site". Biochemical and Biophysical Research Communications. 297 (2): 224–231. doi:10.1016/S0006-291X(02)02154-X. PMID 12237106.