Bisbiguanide

Bisbiguanides are a class of chemically related compounds known for their bactericidal properties. Generally considered to be of the generic formula: R1 R2 N.C(:NR6)NH.C(:NH)NH.CH2 X--(CH2)3 NH.C(:NH)NH.C(:NR7)NR3 R4 V.[1] These compounds include the antiseptics chlorhexidine and alexidine[2] (but not, as suggested here previously, octenidine).

Structure of chlorhexidine, a bisbiguanide antiseptic.

References
  1. Bisbiguanide compounds - Patent 4670592
  2. Tanzer JM, Slee AM, Kamay BA (1977). "Structural requirements of guanide, biguanide, and bisbiguanide agents for antiplaque activity". Antimicrob. Agents Chemother. 12 (6): 721–9. doi:10.1128/aac.12.6.721. PMC 430011. PMID 931371.


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