C11orf16

The gene C11orf16 is located on chromosome 11(p15.4), starting at 8,920,076bp and ending at 8,933,006bp.

Gene ASCL3 and AKIP1 are the neighbor genes of C11orf16 on chromosome 11.

The gene does not have high expression throughout the body tissues. The percentile rank within the sample are higher in pancreas, ovary, and appendix.

C11orf16 expression in human body sites extracted from NCBI GEO profile

Even though the gene does not have a significant high expression in the mouse brain, it is most expressed in midbrain, isocortex, olfactory areas, and medulla.

Some transcription factors that have the higher matrix similarity are Kruppel-like zinc finger protein 219, zinc finger protein 263, ZKSCAN12 (zinc finger protein with KRAB and SCAN domains 12), chorion-specific transcription factor GCMa, and Ras-responsive element binding protein 1.[7]

The predicted C11orf16 transcript variant X1 is 2386bp long and has NCBI accession number of XM_017018013.1.[8]

No paralogs were found for the C11orf16 gene through NCBI BLAST.

The gene C11orf16 is conserved in many animal species including mammals, avians, and reptiles.

The multiple sequence alignment shows the conservation of the gene C11orf16

The predicted molecular weight of the protein encoded by C11orf16 is 51 kiloDaltons.[9][10]

Several protein domains and motifs were found including CHD5-like protein, tyrosine kinase phosphorylation site, protein kinase C phosphorylation site, N-myristoylation site, casein kinase II phosphorylation site, and cGMP-dependent protein kinase phosphorylation site.[11] The picture indicates the location of the motifs.

The predicted motifs of C11orf16 are shown in colors to the corresponding amino acids

The protein is predicted to be made up with 21.2% of alpha helix, 15.2% of extended strand, and 63% of random coil.

The secondary structure of protein C11orf16

No transmembrane helices,[12] potential GPI-modification sites, or TM-proteins were found. There were seven predicted sumoylation sites,[13] multiple phosporylation cites with most of them being unsp,[14] and nine glycosylation sites.[15]

Post translational modification of protein C11orf16[16]

The protein is predicted to be localized to the nucleus with the probability of 47.8%; mitochondria with the probability of 26.1%.[17]

Proteins C1orf105 (Chromosome 1 open reading frame 105), PWWP2A, and SMYD1(SET and MYND domain containing 1) were found to be interacting with C11orf16.[18]

Protein coded by C11orf16 gene is also predicted to have 19.61% sequence identity to tumor suppressor p53-binding protein suggesting that this gene might be involved with tumor suppressing process.[19]