CBX8

Chromobox protein homolog 8 is a protein that in humans is encoded by the CBX8 gene.[5][6]

CBX8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCBX8, PC3, RC1, chromobox 8
External IDsOMIM: 617354 MGI: 1353589 HomoloGene: 32199 GeneCards: CBX8
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q25.3Start79,792,132 bp[1]
End79,801,683 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

57332

30951

Ensembl

ENSG00000141570

ENSMUSG00000025578

UniProt

Q9HC52

Q9QXV1

RefSeq (mRNA)

NM_020649

NM_013926

RefSeq (protein)

NP_065700

NP_038954

Location (UCSC)Chr 17: 79.79 – 79.8 MbChr 11: 119.04 – 119.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

CBX8 has been shown to interact with RING1[7] and MLLT1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000141570 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025578 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Bardos JI, Saurin AJ, Tissot C, Duprez E, Freemont PS (Oct 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J Biol Chem. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. PMID 10825164.
  6. "Entrez Gene: CBX8 chromobox homolog 8 (Pc class homolog, Drosophila)".
  7. Bárdos, J I; Saurin A J; Tissot C; Duprez E; Freemont P S (Sep 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J. Biol. Chem. 275 (37): 28785–92. doi:10.1074/jbc.M001835200. ISSN 0021-9258. PMID 10825164.
  8. García-Cuéllar, M P; Zilles O; Schreiner S A; Birke M; Winkler T H; Slany R K (Jan 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. ISSN 0950-9232. PMID 11313972.

Further reading


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