CD3EAP

DNA-directed RNA polymerase I subunit RPA34 is an enzyme that in humans is encoded by the CD3EAP gene.[5][6][7][8]

POLR1G
Identifiers
AliasesPOLR1G, ASE-1, ASE1, CAST, PAF49, CD3e molecule associated protein, RPA34, RNA polymerase I subunit G, CD3EAP
External IDsOMIM: 107325 MGI: 1917583 HomoloGene: 17107 GeneCards: POLR1G
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.32Start45,406,209 bp[1]
End45,410,766 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10849

70333

Ensembl

ENSG00000117877

ENSMUSG00000047649

UniProt

O15446

Q76KJ5

RefSeq (mRNA)

NM_012099
NM_001297590

NM_145822

RefSeq (protein)

NP_001284519
NP_036231

NP_665821

Location (UCSC)Chr 19: 45.41 – 45.41 MbChr 7: 19.36 – 19.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

CD3EAP has been shown to interact with T-cell surface glycoprotein CD3 epsilon chain,[5] POLR1E[7] and POLR1C.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000117877 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000047649 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yamazaki T, Hamano Y, Tashiro H, Itoh K, Nakano H, Miyatake S, Saito T (Jul 1999). "CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells". J Biol Chem. 274 (26): 18173–80. doi:10.1074/jbc.274.26.18173. PMID 10373416.
  6. Whitehead CM, Winkfein RJ, Fritzler MJ, Rattner JB (Mar 1998). "ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes". Chromosoma. 106 (8): 493–502. doi:10.1007/s004120050271. PMID 9426281. S2CID 10684078.
  7. Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (Jun 2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol Cell Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
  8. "Entrez Gene: CD3EAP CD3e molecule, epsilon associated protein".

Further reading


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