CDH17

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.[5][6][7]

CDH17
Identifiers
Aliases	CDH17, CDH16, HPT-1, HPT1, cadherin 17
External IDs	OMIM: 603017 MGI: 1095414 HomoloGene: 56859 GeneCards: CDH17
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.1 Start 94,127,162 bp[1] End 94,217,303 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A1 Start 11,758,147 bp[2] End 11,817,895 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • transporter activity • metal ion binding • integrin binding • proton-dependent oligopeptide secondary active transmembrane transporter activity • cytoskeletal protein binding • protein homodimerization activity • cadherin binding Cellular component • integral component of membrane • membrane • cell surface • cell membrane • basolateral plasma membrane • cell nucleus • cell junction • catenin complex Biological process • spleen development • marginal zone B cell differentiation • integrin-mediated signaling pathway • positive regulation of integrin activation by cell surface receptor linked signal transduction • germinal center B cell differentiation • B cell differentiation • adherens junction organization • oligopeptide transport • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules • oligopeptide transmembrane transport • homophilic cell adhesion via plasma membrane adhesion molecules • cell adhesion • cell-cell junction assembly • cell-cell adhesion mediated by cadherin • cell-cell adhesion • cell morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1015	12557
Ensembl	ENSG00000079112	ENSMUSG00000028217
UniProt	Q12864	Q9R100
RefSeq (mRNA)	NM_001144663 NM_004063	NM_019753
RefSeq (protein)	NP_001138135 NP_004054	NP_062727
Location (UCSC)	Chr 8: 94.13 – 94.22 Mb	Chr 4: 11.76 – 11.82 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.[7]