CIDEB

CIDEB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D4B
Identifiers
Aliases	CIDEB, cell death-inducing DFFA-like effector b, cell death inducing DFFA like effector b
External IDs	OMIM: 604441 MGI: 1270844 HomoloGene: 7666 GeneCards: CIDEB
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	24,311,430 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	55,758,458 bp[2]
Gene ontology
Molecular function	• GO:0001948 protein binding; • identical protein binding;
Cellular component	• perinuclear region of cytoplasm; • cytosol; • lipid droplet; • intracellular;
Biological process	• positive regulation of release of cytochrome c from mitochondria; • execution phase of apoptosis; • activation of cysteine-type endopeptidase activity; • positive regulation of cell death; • intrinsic apoptotic signaling pathway in response to DNA damage; • apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	27141
	12684
	ENSG00000136305; ENSG00000285199
	ENSMUSG00000022219
	Q9UHD4
	O70303
	NM_014430; NM_001318807
	NM_009894; NM_026804
	NP_001305736; NP_055245
	NP_034024
	Wikidata
View/Edit Human	View/Edit Mouse

Cell death-inducing DFFA-like effector b, also known as CIDEB, is a human gene.[5][6][7]

Recently, CIDEB knockout mice have been generated by homolog recombination technique. The CIDE null mice show decreased lipogenesis. The CIDEB knockout mice are resistant to high fat diet induced obesity and liver steatosis. In addition, the CIDEB null mice also have improved insulin sensitivity and enhanced hepatic fatty acid oxidation and whole body metabolism.[8]

References

ENSG00000285199 GRCh38: Ensembl release 89: ENSG00000136305, ENSG00000285199 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022219 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: CIDEB cell death-inducing DFFA-like effector b".
Ye, Jing; Zhong Li, John; Liu, Yang; Li, Xuanhe; Yang, Tianshu; Ma, Xiaodong; Li, Qing; Yao, Zemin; Li, Peng (2009). "Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B.". Cell Metabolism. 9 (2): 177–190. doi:10.1016/j.cmet.2008.12.013. PMID 19187774.
Li, JZ; Lei, Y; Wang, Y; Zhang, Y; Ye, J; Xia, X; Pan, X; Li, P (May 2010). "Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb". Biochim Biophys Acta. 1801 (5): 577–86. doi:10.1016/j.bbalip.2010.01.012. PMID 20123130.
Zhong Li, John; Ye, Jing; Xue, Bofu; Qi, Jingzong; Zhang, Jing; Zhou, Zhihong; Li, Qing; Wen, Zilong; Li, Peng (2007). "Cideb regulates diet-induced obesity, liver steatosis and insulin sensitivity by controlling lipogeneis and fatty acid oxidation". Diabetes. 56 (10): 2523–2532. doi:10.2337/db07-0040. PMID 17646209.

Inohara N, Koseki T, Chen S, et al. (1998). "CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor". EMBO J. 17 (9): 2526–33. doi:10.1093/emboj/17.9.2526. PMC 1170594. PMID 9564035.
Lugovskoy AA, Zhou P, Chou JJ, et al. (2000). "Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis". Cell. 99 (7): 747–55. doi:10.1016/S0092-8674(00)81672-4. PMID 10619428.
Chen Z, Guo K, Toh SY, et al. (2000). "Mitochondria localization and dimerization are required for CIDE-B to induce apoptosis". J. Biol. Chem. 275 (30): 22619–22. doi:10.1074/jbc.C000207200. PMID 10837461.
Liang L, Zhao M, Xu Z, et al. (2003). "Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family". Biochem. J. 370 (Pt 1): 195–203. doi:10.1042/BJ20020656. PMC 1223158. PMID 12429024.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Erdtmann L, Franck N, Lerat H, et al. (2003). "The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis". J. Biol. Chem. 278 (20): 18256–64. doi:10.1074/jbc.M209732200. PMID 12595532.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Da L, Li D, Yokoyama KK, et al. (2006). "Dual promoters control the cell-specific expression of the human cell death-inducing DFF45-like effector B gene". Biochem. J. 393 (Pt 3): 779–88. doi:10.1042/BJ20051027. PMC 1360731. PMID 16248853.
Li JZ, Lei Y, Wang Y, Zhang Y, Ye J, Xia X, Pan X, Li P, et al. (2010). "Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb". Biochim Biophys Acta. 1801 (Pt 5): 577–586. doi:10.1016/j.bbalip.2010.01.012. PMID 20123130.

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[refGRCh38Ensembl-1] ENSG00000285199 GRCh38: Ensembl release 89: ENSG00000136305, ENSG00000285199 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022219 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CIDEB cell death-inducing DFFA-like effector b".

[6] Ye, Jing; Zhong Li, John; Liu, Yang; Li, Xuanhe; Yang, Tianshu; Ma, Xiaodong; Li, Qing; Yao, Zemin; Li, Peng (2009). "Cideb, an ER- and Lipid Droplet-Associated Protein, Mediates VLDL Lipidation and Maturation by Interacting with Apolipoprotein B.". Cell Metabolism. 9 (2): 177–190. doi:10.1016/j.cmet.2008.12.013. PMID 19187774.

[7] Li, JZ; Lei, Y; Wang, Y; Zhang, Y; Ye, J; Xia, X; Pan, X; Li, P (May 2010). "Control of cholesterol biosynthesis, uptake and storage in hepatocytes by Cideb". Biochim Biophys Acta. 1801 (5): 577–86. doi:10.1016/j.bbalip.2010.01.012. PMID 20123130.

[8] Zhong Li, John; Ye, Jing; Xue, Bofu; Qi, Jingzong; Zhang, Jing; Zhou, Zhihong; Li, Qing; Wen, Zilong; Li, Peng (2007). "Cideb regulates diet-induced obesity, liver steatosis and insulin sensitivity by controlling lipogeneis and fatty acid oxidation". Diabetes. 56 (10): 2523–2532. doi:10.2337/db07-0040. PMID 17646209.

CIDEB

References

Further reading