CLIP1

CAP-GLY domain containing linker protein 1, also known as CLIP1, is a protein which in humans is encoded by the CLIP1 gene.[5]

CLIP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLIP1, CLIP, CLIP-170, CLIP170, CYLN1, RSN, CAP-Gly domain containing linker protein 1
External IDsOMIM: 179838 MGI: 1928401 HomoloGene: 74455 GeneCards: CLIP1
Gene location (Human)
Chr.Chromosome 12 (human)[1]
Band12q24.31Start122,271,432 bp[1]
End122,422,632 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6249

56430

Ensembl

ENSG00000130779

ENSMUSG00000049550

UniProt

P30622

Q922J3

RefSeq (mRNA)

NM_001247997
NM_002956
NM_198240

RefSeq (protein)

NP_001234926
NP_002947
NP_937883

Location (UCSC)Chr 12: 122.27 – 122.42 MbChr 5: 123.58 – 123.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

CLIP1 has been shown to interact with IQGAP1,[6] Mammalian target of rapamycin[7] and PAFAH1B1.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000130779 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000049550 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CLIP1 CAP-GLY domain containing linker protein 1".
  6. Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K (Jun 2002). "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170". Cell. 109 (7): 873–85. doi:10.1016/S0092-8674(02)00800-0. PMID 12110184. S2CID 15158637.
  7. Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF (Oct 2002). "The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase". EMBO Reports. 3 (10): 988–94. doi:10.1093/embo-reports/kvf197. PMC 1307618. PMID 12231510.
  8. Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O (May 2002). "LIS1, CLIP-170's key to the dynein/dynactin pathway". Molecular and Cellular Biology. 22 (9): 3089–102. doi:10.1128/MCB.22.9.3089-3102.2002. PMC 133759. PMID 11940666.

Further reading


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