CPSF7

Cleavage and polyadenylation specificity factor subunit 7 is a protein that in humans is encoded by the CPSF7 gene.[5][6]

CPSF7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCPSF7, CFIm59, FLJ12529, cleavage and polyadenylation specific factor 7
External IDsMGI: 1917826 HomoloGene: 11731 GeneCards: CPSF7
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q12.2Start61,402,641 bp[1]
End61,430,031 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

79869

269061

Ensembl

ENSG00000149532

ENSMUSG00000034820

UniProt

Q8N684

Q8BTV2

RefSeq (mRNA)

NM_001136040
NM_001142565
NM_024811

NM_001164272
NM_172302
NM_001362450

RefSeq (protein)

NP_001129512
NP_001136037
NP_079087

NP_001157744
NP_758506
NP_001349379

Location (UCSC)Chr 11: 61.4 – 61.43 MbChr 19: 10.53 – 10.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

CPSF7, also known as CFIm59, is the cleavage factor of two closely associated protein complexes in the 3' untranslated region of a newly synthesized pre-messenger RNA (mRNA) molecule used in gene transcription. [7] CPSF7 is one of three Cleavage and polyadenylation specificity factors (CPSF), the other two being CFIm25 (or CPSF5/NUDT21) and CFIm68 (or CPSF6).

References

  1. GRCh38: Ensembl release 89: ENSG00000149532 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034820 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. "Entrez Gene: FLJ12529 pre-mRNA cleavage factor I, 59 kDa subunit".
  7. Hardy JG, Norbury CJ (August 2016). "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation". Biochemical Society Transactions. 44 (4): 1051–7. doi:10.1042/BST20160078. PMID 27528751.

Further reading


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