CRMP1

Collapsin response mediator protein 1, encoded by the CRMP1 gene, is a human protein of the CRMP family.[5]

CRMP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCRMP1, CRMP-1, DPYSL1, DRP-1, DRP1, ULIP-3, collapsin response mediator protein 1
External IDsOMIM: 602462 MGI: 107793 HomoloGene: 20347 GeneCards: CRMP1
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4p16.2Start5,748,084 bp[1]
End5,893,086 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1400

12933

Ensembl

ENSG00000072832

ENSMUSG00000029121

UniProt

Q14194

P97427

RefSeq (mRNA)

NM_001313
NM_001014809
NM_001288661
NM_001288662

NM_001136058
NM_007765

RefSeq (protein)

NP_001014809
NP_001275590
NP_001275591
NP_001304

NP_001129530
NP_031791

Location (UCSC)Chr 4: 5.75 – 5.89 MbChr 5: 37.24 – 37.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants.[5]

CRMP1 mediates reelin signaling in cortical neuronal migration.[6] Mice deficient in CRMP1 exhibit impaired long-term potentiation and impaired spatial learning and memory.[7]

CRMP1 gene overlaps with another gene called EVC.[8]

Interactions

CRMP1 has been shown to interact with DPYSL2.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000072832 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029121 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: CRMP1 collapsin response mediator protein 1".
  6. Yamashita N, Uchida Y, Ohshima T, Hirai S, Nakamura F, Taniguchi M, Mikoshiba K, Honnorat J, Kolattukudy P, Thomasset N, Takei K, Takahashi T, Goshima Y (December 2006). "Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration". J. Neurosci. 26 (51): 13357–62. doi:10.1523/JNEUROSCI.4276-06.2006. PMC 6674993. PMID 17182786.
  7. Su KY, Chien WL, Fu WM, Yu IS, Huang HP, Huang PH, Lin SR, Shih JY, Lin YL, Hsueh YP, Yang PC, Lin SW (March 2007). "Mice deficient in collapsin response mediator protein-1 exhibit impaired long-term potentiation and impaired spatial learning and memory". J. Neurosci. 27 (10): 2513–24. doi:10.1523/JNEUROSCI.4497-06.2007. PMC 6672508. PMID 17344389.
  8. Ruiz-Perez VL, Ide SE, Strom TM, Lorenz B, Wilson D, Woods K, King L, Francomano C, Freisinger P, Spranger S, Marino B, Dallapiccola B, Wright M, Meitinger T, Polymeropoulos MH, Goodship J (March 2000). "Mutations in a new gene in Ellis-van Creveld syndrome and Weyers acrodental dysostosis". Nat. Genet. 24 (3): 283–6. doi:10.1038/73508. PMID 10700184. S2CID 1391136.
  9. Leung, Thomas; Ng Yvonne; Cheong Albert; Ng Chong Han; Tan Ivan; Hall Christine; Lim Louis (Dec 2002). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. ISSN 0014-5793. PMID 12482610. S2CID 45499981.

Further reading


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