Calista Flockhart

In spring 1989, Flockhart made her first television appearance in a minor role in an episode of Guiding Light as a babysitter. Also, she played a teenager battling an eating disorder on a one-hour Afternoon Special on TV. Flockhart made her professional debut on the New York stage, appearing in Beside Herself alongside Melissa Joan Hart, at the Circle Repertory Theatre. Two years later, Flockhart appeared in the television movie Darrow. Though she later appeared in films Naked in New York (1993) and Getting In (1994), her first substantial speaking part in a film was in Quiz Show, directed by Robert Redford.

Flockhart debuted on Broadway in 1994, as Laura in The Glass Menagerie. Actress Julie Harris felt Flockhart should be hired without further auditions, claiming that she seemed ideal for the part. Flockhart received a Clarence Derwent Award for her performance. In 1995, Flockhart became acquainted with actors such as Dianne Wiest and Faye Dunaway when she appeared in the movie Drunks. Later that year, Flockhart starred in Jane Doe as a drug addict. In 1996, Flockhart appeared as the daughter of Dianne Wiest and Gene Hackman's characters in The Birdcage. Throughout that year, she continued to work on Broadway, playing the role of Natasha in Anton Chekhov's Three Sisters.

In 1997, Flockhart was asked to audition for the starring role in David E. Kelley's Fox television series Ally McBeal. Kelley, having heard of Flockhart, wanted her to audition for the contract part. Though she initially hesitated due to the necessary commitment to the show in a negotiable contract, she was swayed by the script and traveled to Los Angeles to audition for the part, which she won. She earned a Golden Globe Award for the role in 1998. Flockhart also appeared on the June 29, 1998, cover of Time magazine,[7] placed as the newest iteration in the evolution of feminism, relating to the ongoing debate about the role depicted by her character.[8] Flockhart starred on the show until it was canceled in 2002.[9]

Flockhart performed in a starring role as Kitty Walker, opposite Sally Field, Rachel Griffiths and Matthew Rhys, in the ABC critically acclaimed prime time series Brothers & Sisters, which premiered in September 2006 in the time slot after Desperate Housewives. The show was cancelled in May 2011 after running for five years. Flockhart's character was significant throughout the series' first four years, but her appearances were reduced for the 2010–2011 season, coinciding with the departure of TV husband Rob Lowe.

Flockhart played the role of Helena in A Midsummer Night's Dream, a 1999 film version of Shakespeare's play. In 2000, she appeared in Things You Can Tell Just by Looking at Her and Bash: Latter-Day Plays, later accompanying Eve Ensler to Kenya in order to protest violence against women, particularly female genital mutilation. Flockhart also starred in the Off-Broadway production of Ensler's The Vagina Monologues.

In 2004, Flockhart appeared as Matthew Broderick's deranged girlfriend in The Last Shot. In the same year, Flockhart travelled to Spain for the filming of Fragile, which premiered in September 2005 at the Venice Film Festival. She was offered the role of Susan Mayer on Desperate Housewives but declined, and the role later went to Teri Hatcher.[10]

In 2014, Flockhart landed a role in Full Circle's second season, as mob boss Ellen. It was expected to air in 2015. This had been Flockhart's first acting role in three years, after her hiatus when Brothers & Sisters ended.

In 2015, Flockhart was cast in the television series Supergirl as Cat Grant, a "self-made media magnate and founder of CatCo" and boss to Kara (Supergirl's alter ego).[11] The series premiered on October 26, 2015, on CBS.[12] Due to the network's wish to reduce the show's budget, it was moved to sister network The CW after its first season, along with a move to filming in Vancouver. Flockhart remained with the show (albeit as a recurring character), despite her previous aversion to working outside Los Angeles.[13]