Carl Axel Gemzell

Carl Axel Gemzell (January 4, 1910 in Motala, Sweden – February 11, 2007 in Norrtälje, Sweden) was a Swedish medical doctor and pioneer in reproductive endocrinology.

Life

Gemzell studied medicine at the Karolinska Institute and was registered as a physician in 1940.[1] After training in surgery and obstetrics and gynecology he studied experimental endocrinology at the Wenner-Gren Institute and received his PhD in 1948. Subsequently, he worked at the Institute for Experimental Biology of the University of California, Berkeley before returning to Sweden. He became professor in Ob-Gyn at the Uppsala University Faculty of Medicine. After his mandatory retirement in Sweden in 1975, he moved to the USA where he continued to work at SUNY Downstate Medical Center, Brooklyn, New York, and later at the University of Puerto Rico in San Juan before he retired in Florida and, after the death of his wife, returned to Sweden.

Work

Gemzell developed methods to extract the human growth hormone and human gonadotropins from cadaver pituitary glands. In 1958 Gemzell was the first to show that extracted gonadotropins containing FSH could be used as fertility medication to stimulate ovulation in women with anovulatory infertility. Ovulation stimulation using FSH medication became the basis of modern infertility therapy such as IVF. First pregnancies were achieved in 1961 and Gemzell recognized early that multiple pregnancy and the ovarian hyperstimulation syndrome were major side effect of the therapy.[2] Gemzell's pituitary gonadotropin preparation was soon replaced by FSH extracts from urine of postmenopausal women by a method that was developed by Piero Donini and later marketed as Pergonal. Decades later pituitary extractions were proven to be unsafe as Creutzfeldt–Jakob disease could be transmitted.[3]

In 1960 Gemzell and Leif Wide presented a pregnancy test based on in-vitro hemagglutination inhibition, a first step away from in-vivo pregnancy testing.[4][5] This test initiated a series of improvements in pregnancy testing leading to the contemporary at-home testing.[5]

Gemzell was a collector of modern paintings and drawings. A part of his collection was publicly exhibited at the Moderna Museet in Stockholm in 1996.

The Gemzell Prize is awarded annually to medical researchers by the University of Uppsala since 1977.

Key publications
  • 1958, First report using pituitary FSH [6]
  • 1960, "An immunological pregnancy test"[7]
  • 1962, "Induction of ovulation with human pituitary gonadotrophins"[8]
  • 1966, Review of clinical results using pituitary FSH for anovulatory women[9]

References
  1. Bettendorf G (1995). "Gemzell, Carl Axel". Gemzell, Carl Axel, in Zur Geschichte der Endokrinologie und Reproduktionsmedizin. Springer Berlin Heidelberg. pp. 174–176. doi:10.1007/978-3-642-79152-9_73. ISBN 978-3-642-79153-6.
  2. "The Fantastic Drug That Creates Quintuplets". Life. August 13, 1965. p. 24ff. Retrieved July 7, 2014.
  3. Robert G. Edwards (October 2001). "The bumpy road to human in vitro fertilization" (PDF). Nature Medicine. 7 (10): 1091–1094. doi:10.1038/nm1001-1091. PMID 11590421. Archived from the original (PDF) on September 9, 2013. Retrieved July 7, 2014.
  4. Bleavins MR, Carini C, Malle JR, Rahbari R (2010). Biomarkers in Drug Development: A Handbook of Practice, Application, and Strategy, Chapter 1, Blood and Urine Chemistry. John Wiley and Sons. ISBN 978-0-470-16927-8.
  5. Wide L (2005). "Inventions leading to the development of the diagnostic test kit industry--from the modern pregnancy test to the sandwich assays". Upsala Journal of Medical Sciences. 110 (3): 193–216. doi:10.3109/2000-1967-066. PMID 16454158.
  6. Gemzell, C. A.; Diczfalusy, E; Tillinger, G (1958). "Clinical effect of human pituitary follicle-stimulating hormone (FSH)". The Journal of Clinical Endocrinology and Metabolism. 18 (12): 1333–48. doi:10.1210/jcem-18-12-1333. PMID 13611018.
  7. Wide, L; Gemzell, C. A. (1960). "An immunological pregnancy test". Acta Endocrinologica. 35: 261–7. doi:10.1530/acta.0.xxxv0261. PMID 13785019.
  8. Gemzell, C. A. (1962). "Induction of ovulation with human pituitary gonadotrophins". Fertility and Sterility. 13 (2): 153–68. doi:10.1016/s0015-0282(16)34445-4. PMID 13897660.
  9. Gemzell, C. A.; Roos, P; Loeffler, F. E. (1966). "The clinical use of pituitary gonadotrophins in women". Journal of Reproduction and Fertility. 12 (1): 49–64. doi:10.1530/jrf.0.0120049. PMID 5330083.
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