Complement component 4B

Complement component 4B (Chido blood group) is a protein that in humans is encoded by the C4B gene.[5]

C4B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesC4B, C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4F, CH, CO4, CPAMD3, Complement component 4B, complement component 4B (Chido blood group), complement C4B (Chido blood group)
External IDsOMIM: 120820 MGI: 88228 HomoloGene: 36030 GeneCards: C4B
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.33Start32,014,795 bp[1]
End32,035,418 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

721

12268

Ensembl

ENSMUSG00000073418

UniProt

P0C0L4
P0C0L5

P01029

RefSeq (mRNA)

NM_001002029

NM_009780

RefSeq (protein)

NP_001239133
NP_009224
NP_001229752

NP_033910

Location (UCSC)Chr 6: 32.01 – 32.04 MbChr 17: 34.73 – 34.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, Jul 2008].[5]

See also


References

Further reading


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