Cytoreductive surgery

Cytoreductive surgery is a surgical procedure used to remove tumors from patients with peritoneal mesothelioma. "Cytoreduction" refers to reducing the number of tumor cells.

When it's paired with hyperthermic intraperitoneal chemotherapy (HIPEC), it considerably increases life expectancy and reduces the rate of cancer recurrence.

Its main developer was Paul Sugarbaker which is known for the instauration of cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy,[1] or HIPEC, a treatment alternately referred to as the Sugarbaker Procedure.[2][3]

Ovarian cancer

Among patients with stage III epithelial ovarian cancer, the addition of HIPEC to interval cytoreductive surgery resulted in longer recurrence-free survival and overall survival than surgery alone and did not result in higher rates of side effects.[4]

References

Neuwirth, Madalyn G.; Alexander, H. Richard; Karakousis, Giorgos C. (February 1, 2016). "Then and now: cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC), a historical perspective". Journal of Gastrointestinal Oncology. 7 (1): 18–28. doi:10.3978/j.issn.2078-6891.2015.106. ISSN 2078-6891. PMC 4754315. PMID 26941981.
Pollack, Andrew (2011-08-11). "Heated, Harrowing Chemotherapy Bath May Be Only Hope for Some". The New York Times. ISSN 0362-4331. Retrieved 2018-04-22.
Wilber, Del Quentin (2012-11-25). "Surgeon performs controversial cancer surgery named after him". Washington Post. ISSN 0190-8286. Retrieved 2018-04-22.
van Driel, Willemien J.; Koole, Simone N.; Sikorska, Karolina; Schagen van Leeuwen, Jules H.; Schreuder, Henk W.R.; Hermans, Ralph H.M.; de Hingh, Ignace H.J.T.; van der Velden, Jacobus; Arts, Henriëtte J. (2018-01-18). "Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer". New England Journal of Medicine. 378 (3): 230–240. doi:10.1056/nejmoa1708618. hdl:1874/364110. ISSN 0028-4793. PMID 29342393.

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[1] Neuwirth, Madalyn G.; Alexander, H. Richard; Karakousis, Giorgos C. (February 1, 2016). "Then and now: cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC), a historical perspective". Journal of Gastrointestinal Oncology. 7 (1): 18–28. doi:10.3978/j.issn.2078-6891.2015.106. ISSN 2078-6891. PMC 4754315. PMID 26941981.

[2] Pollack, Andrew (2011-08-11). "Heated, Harrowing Chemotherapy Bath May Be Only Hope for Some". The New York Times. ISSN 0362-4331. Retrieved 2018-04-22.

[wapo-3] Wilber, Del Quentin (2012-11-25). "Surgeon performs controversial cancer surgery named after him". Washington Post. ISSN 0190-8286. Retrieved 2018-04-22.

[4] van Driel, Willemien J.; Koole, Simone N.; Sikorska, Karolina; Schagen van Leeuwen, Jules H.; Schreuder, Henk W.R.; Hermans, Ralph H.M.; de Hingh, Ignace H.J.T.; van der Velden, Jacobus; Arts, Henriëtte J. (2018-01-18). "Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer". New England Journal of Medicine. 378 (3): 230–240. doi:10.1056/nejmoa1708618. hdl:1874/364110. ISSN 0028-4793. PMID 29342393.