DEFA4

Defensin, alpha 4 (DEFA4), also known as neutrophil defensin 4 or HNP4, is a human defensin peptide that is encoded by the DEFA4 gene.[3][4] HNP4 is expressed in the granules of the neutrophil where it defends the host against bacteria[5] and viruses.[6]

DEFA4
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesDEFA4, DEF4, HNP-4, HP-4, HP4, defensin alpha 4
External IDsOMIM: 601157 HomoloGene: 48059 GeneCards: DEFA4
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8p23.1Start6,935,820 bp[1]
End6,938,306 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

1669

n/a

Ensembl

ENSG00000164821
ENSG00000285318

n/a

UniProt

P12838

n/a

RefSeq (mRNA)

NM_001925

n/a

RefSeq (protein)

NP_001916

n/a

Location (UCSC)Chr 8: 6.94 – 6.94 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

Defensins are a peptide family of cytotoxic microbicides involved in innate immunity.[7] Members of the defensin family are distinguished by a conserved six-cysteine motif. Several human alpha defensin genes including HNP4 are clustered on chromosome 8. DEFA4 differs from other defensin genes by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. HNP4 inhibits corticotropin-stimulated corticosterone production.[3]

References

  1. ENSG00000285318 GRCh38: Ensembl release 89: ENSG00000164821, ENSG00000285318 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Entrez Gene: DEFA4; defensin, alpha 4, corticostatin (Homo sapiens)".
  4. Wu Z, Ericksen B, Tucker K, et al. (2004). "Synthesis and characterization of human alpha-defensins 4-6". J Pept Res. 64 (3): 118–25. doi:10.1111/j.1399-3011.2004.00179.x. PMID 15317502.
  5. Ericksen B, Wu Z, Lu W, Lehrer RI (2005). "Antibacterial Activity and Specificity of the Six Human α-Defensins". Antimicrob. Agents Chemother. 49 (1): 269–75. doi:10.1128/AAC.49.1.269-275.2005. PMC 538877. PMID 15616305.
  6. Wu Z, Cocchi F, Gentles D, et al. (3 January 2005). "Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro". FEBS Lett. 579 (1): 162–6. doi:10.1016/j.febslet.2004.11.062. PMID 15620707. S2CID 84062495.
  7. T Ganz; M E Selsted; D Szklarek; et al. (1985). "Defensins. Natural peptide antibiotics of human neutrophils". J Clin Invest. 76 (4): 1427–1435. doi:10.1172/JCI112120. PMC 424093. PMID 2997278.

Further reading



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