DLL4

Delta-like 4 is a protein that in humans is encoded by the DLL4 gene.[5][6]

DLL4
Identifiers
AliasesDLL4, hdelta2, AOS6, delta like canonical Notch ligand 4, delta4
External IDsOMIM: 605185 MGI: 1859388 HomoloGene: 10411 GeneCards: DLL4
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q15.1Start40,929,340 bp[1]
End40,939,073 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

54567

54485

Ensembl

ENSG00000128917

ENSMUSG00000027314

UniProt

Q9NR61

Q9JI71

RefSeq (mRNA)

NM_019074

NM_019454

RefSeq (protein)

NP_061947

NP_062327

Location (UCSC)Chr 15: 40.93 – 40.94 MbChr 2: 119.33 – 119.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000128917 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027314 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Shutter JR, Scully S, Fan W, Richards WG, Kitajewski J, Deblandre GA, Kintner CR, Stark KL (June 2000). "Dll4, a novel Notch ligand expressed in arterial endothelium". Genes & Development. 14 (11): 1313–8. doi:10.1101/gad.14.11.1313 (inactive 2021-01-11). PMC 316657. PMID 10837024.CS1 maint: DOI inactive as of January 2021 (link)
  6. "Entrez Gene: DLL4 delta-like 4 (Drosophila)".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q9NR61 (Delta-like protein 4) at the PDBe-KB.
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