DTX1

DTX1
Identifiers
Aliases	DTX1, hDx-1, deltex 1, deltex E3 ubiquitin ligase 1, RNF140
External IDs	OMIM: 602582 MGI: 1352744 HomoloGene: 74522 GeneCards: DTX1
Gene location (Human)
Chr.	Chromosome 12 (human)[1]
End	113,098,028 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	120,711,927 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• SH3 domain binding; • GO:0001105 transcription coactivator activity; • zinc ion binding; • GO:0001948 protein binding; • ubiquitin protein ligase binding; • metal ion binding; • Notch binding; • transferase activity;
Cellular component	• cytoplasm; • cell nucleus; • nucleoplasm; • cytosol; • nuclear body;
Biological process	• Notch signaling pathway; • cell surface receptor signaling pathway; • glial cell differentiation; • transcription from RNA polymerase II promoter; • regulation of Notch signaling pathway; • negative regulation of T cell differentiation; • negative regulation of neuron differentiation; • protein ubiquitination; • transcription, DNA-templated; • cellular response to leukemia inhibitory factor; • positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	1840
	14357
	ENSG00000135144
	ENSMUSG00000029603
	Q86Y01
	Q61010
	NM_004416
	NM_008052
	NP_004407
	NP_032078
	Wikidata
View/Edit Human	View/Edit Mouse

Protein deltex-1 is a protein that in humans is encoded by the DTX1 gene.[5][6]

Function

Studies in Drosophila have identified this gene as encoding a positive regulator of the notch signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.[6]

Interactions

DTX1 has been shown to interact with EP300.[7]

References

GRCh38: Ensembl release 89: ENSG00000135144 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000029603 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S (May 1998). "Human deltex is a conserved regulator of Notch signalling". Nature Genetics. 19 (1): 74–8. doi:10.1038/ng0598-74. PMID 9590294. S2CID 6812613.
"Entrez Gene: DTX1 deltex homolog 1 (Drosophila)".
Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M (Nov 2001). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". The Journal of Biological Chemistry. 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.

Saito T, Chiba S, Ichikawa M, Kunisato A, Asai T, Shimizu K, Yamaguchi T, Yamamoto G, Seo S, Kumano K, Nakagami-Yamaguchi E, Hamada Y, Aizawa S, Hirai H (May 2003). "Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development". Immunity. 18 (5): 675–85. doi:10.1016/S1074-7613(03)00111-0. PMID 12753744.
Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (Jun 2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". The Journal of Biological Chemistry. 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957.
Gupta-Rossi N, Storck S, Griebel PJ, Reynaud CA, Weill JC, Dahan A (Mar 2003). "Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells". Molecular Immunology. 39 (13): 791–9. doi:10.1016/S0161-5890(03)00002-6. PMID 12617994.
Izon DJ, Aster JC, He Y, Weng A, Karnell FG, Patriub V, Xu L, Bakkour S, Rodriguez C, Allman D, Pear WS (Feb 2002). "Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1". Immunity. 16 (2): 231–43. doi:10.1016/S1074-7613(02)00271-6. PMID 11869684.
Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M (Nov 2001). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". The Journal of Biological Chemistry. 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.
Kishi N, Tang Z, Maeda Y, Hirai A, Mo R, Ito M, Suzuki S, Nakao K, Kinoshita T, Kadesch T, Hui C, Artavanis-Tsakonas S, Okano H, Matsuno K (Feb 2001). "Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis". International Journal of Developmental Neuroscience. 19 (1): 21–35. doi:10.1016/S0736-5748(00)00071-X. PMID 11226752. S2CID 21859491.
Lee L, Dowhanick-Morrissette J, Katz A, Jukofsky L, Krantz ID (Dec 2000). "Chromosomal localization, genomic characterization, and mapping to the Noonan syndrome critical region of the human Deltex (DTX1) gene". Human Genetics. 107 (6): 577–81. doi:10.1007/s004390000431. PMID 11153911. S2CID 38695463.
Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (Jul 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell. 90 (2): 281–91. doi:10.1016/S0092-8674(00)80336-0. PMID 9244302. S2CID 16544864.
Matsuno K, Diederich RJ, Go MJ, Blaumueller CM, Artavanis-Tsakonas S (Aug 1995). "Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats". Development. 121 (8): 2633–44. PMID 7671825.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135144 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029603 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9590294-5] Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S (May 1998). "Human deltex is a conserved regulator of Notch signalling". Nature Genetics. 19 (1): 74–8. doi:10.1038/ng0598-74. PMID 9590294. S2CID 6812613.

[entrez-6] "Entrez Gene: DTX1 deltex homolog 1 (Drosophila)".

[pmid11564735-7] Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M (Nov 2001). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". The Journal of Biological Chemistry. 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.

DTX1

Function

Interactions

References

Further reading