Daf-12

The DAF-12 (abnormal dauer formation protein 12) gene encodes the nuclear receptor of dafachronic acid (a steroid hormone) in the worm Caenorhabditis elegans, with the NRNC Symbol NR1J1 as the homolog of nuclear hormone receptor HR96 (Hr96) in Drosophila melanogaster.[1] DAF-12 has been implicated by Cynthia Kenyon and colleagues in the formation of Dauer larva.[2]

Nuclear hormone receptor family member daf-12
Identifiers
OrganismCaenorhabditis elegans
Symboldaf-12
Alt. symbolsNR1J1
Entrez181263
RefSeq (mRNA)NM_001029376.5
RefSeq (Prot)NP_001024547.1
UniProtG5EFF5
Other data
ChromosomeX: 10.64 - 10.67 Mb

In favorable environments, a cytochrome p450 Daf-9 (Cyp22a1)[3] produce dafachronic acid to binding Daf-12 to initiating downstream gene expression.[4] When in infavorable environments, like starvation, dafachronic acid decreases, Daf-12 will form a complex with co-repressor DIN-1.[5]

References
  1. Kaur S, Jobling S, Jones CS, Noble LR, Routledge EJ, Lockyer AE (7 April 2015). "The nuclear receptors of Biomphalaria glabrata and Lottia gigantea: implications for developing new model organisms". PLOS ONE. 10 (4): e0121259. Bibcode:2015PLoSO..1021259K. doi:10.1371/journal.pone.0121259. PMC 4388693. PMID 25849443.
  2. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993). "A C. elegans mutant that lives twice as long as wild type". Nature. 366 (6454): 461–464. Bibcode:1993Natur.366..461K. doi:10.1038/366461a0. PMID 8247153.
  3. Jia K, Albert PS, Riddle DL (2002). "DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity". Development. 129 (1): 221–31. PMID 11782415.
  4. Aguilaniu H, Fabrizio P, Witting M (2016). "The Role of Dafachronic Acid Signaling in Development and Longevity in Caenorhabditis elegans: Digging Deeper Using Cutting-Edge Analytical Chemistry". Frontiers in Endocrinology. 7: 12. doi:10.3389/fendo.2016.00012. PMC 4749721. PMID 26903948.
  5. Bento G, Ogawa A, Sommer RJ (July 2010). "Co-option of the hormone-signalling module dafachronic acid-DAF-12 in nematode evolution". Nature. 466 (7305): 494–7. doi:10.1038/nature09164. PMID 20592728.
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