Diagnosis: Murder (season 4)

A friend of Steve's winds up dead in a friendly-fire incident involving a veteran cop, but the shooting may have been planned all along. Kim Johnston Ulrich played the conniving widow. Guest Star: Jonathan Banks.

Sloan and Jesse make contact with a patient who died from a genetically altered strain of smallpox.

After faking an attack on herself just to win endorsements, a skater kills her accomplice and frames her rival.

A string of murders occurs with the same killer signature. One of the victims supposedly called Mark, but it is after she was known to be dead. The case becomes personal when the killer starts calling Mark. Mark gets involved in the string of murders when the killer starts calling Mark. It gets more personal when the killer attacks Amanda. She manages to escape. Mark and Steve get closer to finding the killer.After the killer confessed he didn't killed one of the victims, Mark and Steve look for the copycat murderer.

Sloan and Steve probe the murder of a private eye in the not-so-pretty world of modeling.

A cardiologist and two business partners concoct a devious insurance scam.

A terrorist bombing leads to an undercover investigation involving an ambitious cop.

Sloan discovers a murder victim amongst the trauma patients from a bus accident.

The drug-addicted daughter of a senator is killed during an argument, but a senior aide tries to make it look like an overdose.

Sloan helps a lawyer probe a drive-by shooting at a high school which left a popular teacher dead. But her stubborn insistence that a Korean teen is responsible makes finding the real killer a challenge. Guest Star: Piper Laurie.

Sloan's daughter escapes the wrath of her abusive trucker husband who ends up dead.

Sloan looks for clues to solve the decades-old murder of his mentor.

Sloan enlists his friend Ben Matlock (Andy Griffith) to defend Jesse, who's accused of murdering a resident. Guest Star: Lee Chamberlin.

With Jesse falsely accused of murdering Eric Spindler, Ben Matlock (Andy Griffith) gathers all the evidence to find the real killer. Guest Star: H. Richard Greene. Note: This was Andy Griffiths final appearance as Ben Matlock

Sloan assists Joe Mannix (Mike Connors) with an unsolved murder case from 1973.
Note: This episode serves as a sequel to the Mannix episode "Little Girl Lost". Guest Stars: Richard Gant, Julie Adams, Pernell Roberts, and Beverly Garland.

The prime suspects in the murder of a country star are a driven TV producer and her timid songwriter daughter. Guest Stars: Deanne Bray, Barbara Mandrell, Billy Ray Cyrus, Terri Clark, Linda Davis, Billy Dean, Joe Diffie, Eddie Rabbitt, and Reba McEntire.

A psychiatrist kills his estranged wife and tries to frame a patient. Guest Stars: Dwight Schultz.

A beach boy is suspected of killing his girlfriend's brother – a gang member. Guest Stars: Carey Van Dyke, and Shane Van Dyke.

A surgeon drops dead while operating on another doctor.

A wealthy woman, Claire Whitfield (Brynn Thayer) and her lover cook up an elaborate plot to bump off her husband, Elliott (Wayne Tippit). Brynn Thayer plays Leanne Macintyre on Matlock.

A washed up comedian stumbles in his attempts to murder his more successful partner, whose wife ends up dead in the pool. But evidence soon suggests he might not be responsible. Guest Stars: Harvey Korman, Tim Conway (plays Tim Conrad), and Tom Gallop (plays Phil Zarkin).

A mad bomber whom Sloan helped put away breaks out of prison bent on revenge. Guest Stars: Carol Bruce, and Mary Kay Adams.