Divinyl chlorophyllide a 8-vinyl-reductase

In enzymology, divinyl chlorophyllide a 8-vinyl-reductase (EC 1.3.1.75) is an enzyme that catalyzes the chemical reaction

3,8-divinylprotochlorophyllide + NADPH + H+ protochlorophyllide + NADP+
Divinyl chlorophyllide a 8-vinyl-reductase
Identifiers
EC number1.3.1.75
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The three substrates of this enzyme are 3,8-divinylprotochlorophyllide, NADPH, and H+; its two products are protochlorophyllide and NADP+. This enzyme can also convert alternative substrates, for example 3,8-divinyl chlorophyllide a and in all cases reduces a single specific vinyl group to an ethyl group.

This enzyme belongs to the family of oxidoreductases. The systematic name of this enzyme class is chlorophyllide-a :NADP+ oxidoreductase. Other names in common use include 3,8-divinyl protochlorophyllide a 8-vinyl-reductase, [4-vinyl]chlorophyllide a reductase, and 4VCR. This enzyme is part of the biosynthetic pathway to chlorophylls.

Protochlorophyllide, the product of the reaction

See also

References
    • Tripathy BC; Rebeiz CA (1988). "Chloroplast biogenesis 60. Conversion of divinyl protochlorophyllide to monovinyl protochlorophyllide in green(ing) barley, a dark monovinyl/light divinyl plant species". Plant Physiol. 87: 89–94. doi:10.1104/pp.87.1.89. PMC 1054704. PMID 16666133.
    • Parham R, Rebeiz CA (1992). "Chloroplast biogenesis: [4-vinyl] chlorophyllide a reductase is a divinyl chlorophyllide a-specific, NADPH-dependent enzyme". Biochemistry. 31 (36): 8460–4. doi:10.1021/bi00151a011. PMID 1390630.
    • Parham R, Rebeiz CA (1995). "Chloroplast biogenesis 72: a [4-vinyl]chlorophyllide a reductase assay using divinyl chlorophyllide a as an exogenous substrate". Anal. Biochem. 231 (1): 164–9. doi:10.1006/abio.1995.1516. PMID 8678296.
    • Kolossov VL, Rebeiz CA (2001). "Chloroplast biogenesis 84: solubilization and partial purification of membrane-bound [4-vinyl]chlorophyllide a reductase from etiolated barley leaves". Anal. Biochem. 295 (2): 214–9. doi:10.1006/abio.2001.5195. PMID 11488624.
    • Willows, Robert D. (2003). "Biosynthesis of chlorophylls from protoporphyrin IX". Natural Product Reports. 20 (6): 327–341. doi:10.1039/B110549N. PMID 12828371.
    • Bollivar, David W. (2007). "Recent advances in chlorophyll biosynthesis". Photosynthesis Research. 90 (2): 173–194. doi:10.1007/s11120-006-9076-6. PMID 17370354.</ref>


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