EIF2C2

Protein argonaute-2 is a protein that in humans is encoded by the EIF2C2 gene.[4][5][6]

AGO2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAGO2, EIF2C2, Q10, argonaute 2, RISC catalytic component, PPD, CASC7, LINC00980, argonaute RISC catalytic component 2
External IDsOMIM: 606229 MGI: 2446632 HomoloGene: 81825 GeneCards: AGO2
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q24.3Start140,520,156 bp[1]
End140,635,633 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

27161

239528

Ensembl

ENSG00000123908

ENSMUSG00000036698

UniProt

Q9UKV8

Q8CJG0

RefSeq (mRNA)

NM_001164623
NM_012154

NM_153178

RefSeq (protein)

NP_001158095
NP_036286

NP_694818

Location (UCSC)Chr 8: 140.52 – 140.64 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with Dicer1 and play a role in short-interfering-RNA-mediated gene silencing.[6]

Interactions

EIF2C2 has been shown to interact with

References

  1. GRCh38: Ensembl release 89: ENSG00000123908 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Koesters R, Adams V, Betts D, Moos R, Schmid M, Siermann A, Hassam S, Weitz S, Lichter P, Heitz PU, von Knebel Doeberitz M, Briner J (Dec 1999). "Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression". Genomics. 61 (2): 210–8. doi:10.1006/geno.1999.5951. PMID 10534406.
  5. Sasaki T, Shiohama A, Minoshima S, Shimizu N (Aug 2003). "Identification of eight members of the Argonaute family in the human genome small star, filled". Genomics. 82 (3): 323–30. doi:10.1016/S0888-7543(03)00129-0. PMID 12906857.
  6. "Entrez Gene: EIF2C2 eukaryotic translation initiation factor 2C, 2".
  7. Nelson PT, Hatzigeorgiou AG, Mourelatos Z (March 2004). "miRNP:mRNA association in polyribosomes in a human neuronal cell line". RNA. 10 (3): 387–94. doi:10.1261/rna.5181104. PMC 1370934. PMID 14970384.
  8. Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365. PMID 11914277.
  9. Doi N, Zenno S, Ueda R, Ohki-Hamazaki H, Ui-Tei K, Saigo K (January 2003). "Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors". Curr. Biol. 13 (1): 41–6. doi:10.1016/S0960-9822(02)01394-5. PMID 12526743. S2CID 14650075.
  10. Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA, Nelson DL, Moses K, Warren ST (February 2004). "Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway". Nat. Neurosci. 7 (2): 113–7. doi:10.1038/nn1174. PMID 14703574. S2CID 1146182.
  11. Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, Heinrich C, Hentze MW, Ladurner AG (October 2007). "A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. Struct. Mol. Biol. 14 (10): 897–903. doi:10.1038/nsmb1302. PMID 17891150. S2CID 8136380.

Further reading


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