Euan Ashley

Euan Angus Ashley is Professor of Medicine and Genetics at Stanford University in California. He is founding director of the Center for Inherited Cardiovascular Disease,[1] the Clinical Genomics Program[2] and co-director of Stanford Medicine Catalyst.[3]

Euan Ashley
EmployerStanford University
Known forGenomics, Precision medicine, MyHeart Counts
AwardsNational Innovation Award, American Heart Association NIH Director's New Innovator Award, AHA Council on Genomic and Precision Medicine Medal of Honor

Education and early life

Ashley was born in Scotland and attended the University of Glasgow where he graduated in Physiology and Medicine. He completed residency training in Medicine at the John Radcliffe Hospital in Oxford and received his Doctorate (DPhil) from Christ Church College.[4]

Music

Ashley learned saxophone as a teenager joining the Strathclyde Youth Jazz Orchestra and forming a jazz saxophone quartet with members of its saxophone section. The Hung Drawn Quartet with Raymond MacDonald, Graeme Wilson and Allon Beauvoisin released two albums (Cookin’ with the HDQ and A Train in the Distance). They toured in the US (Philadelphia) and Ontario, Canada in 1994. At Oxford, Ashley led the Oxford University Jazz Orchestra with whom he released the album Know Where you Are with bebop altoist Peter King.

Research

Ashley is best known for his work translating insight from the human genome to medicine.[5][6][7][8] In 2009, he led the team that carried out the first medical interpretation of a human genome.[5] The work was featured at the Unlocking Life's Code Exhibit of the Smithsonian museum and recognised at the White House Office of Science and Technology Policy "Data to Knowledge to Action" event. In 2010, Ashley’s team carried out the first whole genome molecular autopsy.[9] In 2011, they extended their genome medical analysis to the first family sequenced using Illumina technology.[10] In this work, they developed inheritance tools for family genome analysis, inferred recombination sites to the lowest median resolution achieved (below 1kb), and reported chromosome-length computational phasing for the first time. In 2014, Ashley became co-chair of the steering committee of the NIH Undiagnosed Diseases Network (UDN).[11][12] Ashley is a recipient of the National Innovation Award from the American Heart Association (AHA) and a National Institutes of Health (NIH) Director's New Innovator Award.

Ashley is also co-Principal Investigator of the MyHeart Counts study,[13] a launch partner for Apple Inc's ResearchKit platform in 2015.[14] The first tranche of results from this study was published in 2017.[15]

Publications

Ashley has authored one textbook, Cardiology Explained,[16] and over 120 peer reviewed publications.[17]

Press coverage

Ashley has appeared on National Public Radio in the United States as well as the BBC, Japanese national television and the Guardian newspaper discussing genome sequencing and precision medicine.[18] His work has been covered in print by the Wall Street Journal, Technology Review, the Telegraph and others. The first traunch of UDN cases was covered by National Public Radio[19] and the New York Times.[20] He has been interviewed multiple times for local and national news.

The Genome Odyssey

Ashley will publish his first book, The Genome Odyssey: Medical Mysteries and the Incredible Quest to Solve Them[21] on February 23, 2021 with Celadon Books, a division of Macmillan Publishers. From the publisher’s notes, “In The Genome Odyssey, Dr. Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease.”

Companies

AstraZeneca

Ashley is a Non-Executive Director of the pharmaceutical company AstraZeneca.

Personalis

In 2012, Ashley co-founded Personalis,[22] a genome-scale diagnostics company with Stanford colleagues Russ Altman, Atul Butte, Mike Snyder and businessman John West. West was the former CEO of Solexa and managed the sale of its core business to Illumina, Inc.

Deepcell

Ashley is scientific co-founder of Deepcell, a company developing non-invasive diagnostics based on imaging blood cells.

Silicon Valley Exercise Analytics

Ashley is co-founder and Chairman of the Board at Silicon Valley Exercise Analytics (Svexa), a sports intelligence company that combines physical, subjective and biological data to offer optimized training, performance and recovery recommendations for athletes and teams

Personal life

Ashley lives in Stanford, California with his wife, Fiona, and their three children.

References
  1. "Center for Inherited Cardiovascular Disease".
  2. "Clinical Genomics".
  3. "About Us". Stanford Medicine Catalyst.
  4. "Euan A. Ashley | Stanford Medicine Profiles". med.stanford.edu. Retrieved 21 September 2015.
  5. Ashley, Euan A; Butte, Atul J; Wheeler, Matthew T; Chen, Rong; Klein, Teri E; Dewey, Frederick E; Dudley, Joel T; Ormond, Kelly E; Pavlovic, Aleksandra (1 January 2010). "Clinical assessment incorporating a personal genome". The Lancet. 375 (9725): 1525–1535. doi:10.1016/s0140-6736(10)60452-7. PMC 2937184. PMID 20435227.
  6. Dewey, Frederick E.; Chen, Rong; Cordero, Sergio P.; Ormond, Kelly E.; Caleshu, Colleen; Karczewski, Konrad J.; Whirl-Carrillo, Michelle; Wheeler, Matthew T.; Dudley, Joel T. (15 September 2011). "Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence". PLoS Genet. 7 (9): e1002280. doi:10.1371/journal.pgen.1002280. PMC 3174201. PMID 21935354.
  7. Dewey, FE; Grove, ME; Pan, C; Goldstein, BA; Bernstein, JA; Chaib, H; Merker, JD; Goldfeder, RL; Enns, GM; David, SP; Pakdaman, N; Ormond, KE; Caleshu, C; Kingham, K; Klein, TE; Whirl-Carrillo, M; Sakamoto, K; Wheeler, MT; Butte, AJ; Ford, JM; Boxer, L; Ioannidis, JP; Yeung, AC; Altman, RB; Assimes, TL; Snyder, M; Ashley, EA; Quertermous, T (12 March 2014). "Clinical interpretation and implications of whole-genome sequencing". JAMA. 311 (10): 1035–1045. doi:10.1001/jama.2014.1717. ISSN 0098-7484. PMC 4119063. PMID 24618965.
  8. Ashley EA (2016). "Towards precision medicine". Nat Rev Genet. 17 (9): 507–22. doi:10.1038/nrg.2016.86. PMID 27528417.
  9. Dewey, Frederick E.; Wheeler, Matthew T.; Cordero, Sergio; Perez, Marco V.; Pavlovic, Aleks; Pushkarev, Dmitry; Freeman, James V.; Quake, Steve R.; Ashley, Euan A. (5 April 2011). "MOLECULAR AUTOPSY FOR SUDDEN CARDIAC DEATH USING WHOLE GENOME SEQUENCING". Journal of the American College of Cardiology. 57 (14, Supplement): E1159. doi:10.1016/S0735-1097(11)61159-5.
  10. Dewey, Frederick E.; Chen, Rong; Cordero, Sergio P.; Ormond, Kelly E.; Caleshu, Colleen; Karczewski, Konrad J.; Whirl-Carrillo, Michelle; Wheeler, Matthew T.; Dudley, Joel T.; Byrnes, Jake K.; Cornejo, Omar E.; Knowles, Joshua W.; Woon, Mark; Sangkuhl, Katrin; Gong, Li; Thorn, Caroline F.; Hebert, Joan M.; Capriotti, Emidio; David, Sean P.; Pavlovic, Aleksandra; West, Anne; Thakuria, Joseph V.; Ball, Madeleine P.; Zaranek, Alexander W.; Rehm, Heidi L.; Church, George M.; West, John S.; Bustamante, Carlos D.; Snyder, Michael; Altman, Russ B.; Klein, Teri E.; Butte, Atul J.; Ashley, Euan A. (15 September 2011). "Phased Whole-Genome Genetic Risk in a Family Quartet Using a Major Allele Reference Sequence". PLoS Genetics. 7 (9): e1002280. doi:10.1371/journal.pgen.1002280.
  11. Gahl, William A.; Wise, Anastasia L.; Ashley, Euan A. (2015). "The Undiagnosed Diseases Network of the National Institutes of Health". JAMA. 314 (17): 1797–8. doi:10.1001/jama.2015.12249. ISSN 0098-7484. PMID 26375289.
  12. Splinter K, Adams DR, Bacino CA, Bellen HJ, Bernstein JA, Cheatle-Jarvela AM, et al. (2018). "Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease". N Engl J Med. 379 (22): 2131–2139. doi:10.1056/NEJMoa1714458. PMC 6481166. PMID 30304647.
  13. "Team".
  14. "Can Apple's ResearchKit Really Change Medical Research?". Wired. 10 March 2015.
  15. McConnell, Michael V.; Shcherbina, Anna; Pavlovic, Aleksandra; Homburger, Julian R.; Goldfeder, Rachel L.; Waggot, Daryl; Cho, Mildred K.; Rosenberger, Mary E.; Haskell, William L.; Myers, Jonathan; Champagne, Mary Ann; Mignot, Emmanuel; Landray, Martin; Tarassenko, Lionel; Harrington, Robert A.; Yeung, Alan C.; Ashley, Euan A. (2017). "Feasibility of Obtaining Measures of Lifestyle From a Smartphone App The MyHeart Counts Cardiovascular Health Study". JAMA Cardiology. 2 (1): 67–76. doi:10.1001/jamacardio.2016.4395. PMID 27973671.
  16. Ashley EA, Niebauer J. Cardiology Explained. 2001.
  17. https://med.stanford.edu/profiles/euan-ashley?tab=publications
  18. Ashley, Euan A. (2015). "The Precision Medicine Initiative". JAMA. 313 (21): 2119–20. doi:10.1001/jama.2015.3595. ISSN 0098-7484. PMID 25928209.
  19. McClurg, Lesley. "Medical Detectives: The Last Hope For Families Coping With Rare Diseases", NPR, San Francisco, 17 December 2018. Retrieved on 28 January 2019.
  20. Kolata, Gina. "When the Illness Is a Mystery, Patients Turn to These Detectives", The New York Times, New York, 7 January 2019. Retrieved on 28 January 2019.
  21. https://celadonbooks.com/book/the-genome-odyssey/
  22. "Home". Archived from the original on 26 September 2015. Retrieved 17 September 2015.
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