Eukaryotic translation initiation factor 4E family

In molecular biology, the eukaryotic translation initiation factor 4E family (eIF-4E) is a family of proteins that bind to the cap structure of eukaryotic cellular mRNAs.[1] Members of this family recognise and bind the 7-methyl-guanosine-containing (m7Gppp) cap during an early step in the initiation of protein synthesis and facilitate ribosome binding to an mRNA by inducing the unwinding of its secondary structures. A tryptophan in the central part of the sequence of human eIF-4E seems to be implicated in cap-binding.[2]

IF4E
cocrystal structure of eif4e/4e-bp1 peptide
Identifiers
SymbolIF4E
PfamPF01652
InterProIPR001040
PROSITEPDOC00641
SCOP21ap8 / SCOPe / SUPFAM

Members of this family include EIF4E, EIF4E2, EIF4E3 and EIF4E1B.

References

  1. Thach RE (January 1992). "Cap recap: the involvement of eIF-4F in regulating gene expression". Cell. 68 (2): 177–180. doi:10.1016/0092-8674(92)90461-K. PMID 1733496. S2CID 46020706.
  2. Ueda H, Iyo H, Doi M, Inoue M, Ishida T, Morioka H, Tanaka T, Nishikawa S, Uesugi S (March 1991). "Combination of Trp and Glu residues for recognition of mRNA cap structure. Analysis of m7G base recognition site of human cap binding protein (IF-4E) by site-directed mutagenesis". FEBS Lett. 280 (2): 207–10. doi:10.1016/0014-5793(91)80294-D. PMID 1672854. S2CID 11779841.
This article incorporates text from the public domain Pfam and InterPro: IPR001040
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